Evaluation of a new LC method for analysis of vancomycin released from an orthopaedic drug carrier system

Mónika Laki, Mária Hajdú, Krisztina Ludányi, Ákos Zahár, Miklós Szendroi, Imre Klebovich, István Antal

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Because of the increasing spread of antibiotic multiresistance, the drug vancomycin is a commonly used in orthopaedic surgery. The objective of our research was to develop a new method for analysis of the drug carrier systems-i.e. systems providing prolonged drug release-used in orthopaedics. The development of a pharmaceutical formulation requires a simple method for analysis of the active ingredient. For characterization of a drug release profile as a function of time, release of antibiotics from hydrophobic matrices was followed by in vitro tests. A rapid LC method, using a 2.1 mm x 150 mm, 5 μm particle, C18 column and methanol-water-acetate buffer as mobile phase was developed for quantitative analysis of samples taken in drug release studies.

Original languageEnglish
Pages (from-to)S141-S144
JournalChromatographia
Volume68
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Oct 1 2008

Keywords

  • Column liquid chromatography
  • Diode-array detector
  • Drug release
  • Orthopaedic surgery
  • Vancomycin hydrochloride

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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