European surveillance study on antimicrobial susceptibility of Gram-positive anaerobic cocci

J. Brazier, D. Chmelar, L. Dubreuil, G. Feierl, M. Hedberg, S. Kalenic, E. Könönen, B. Lundgren, H. Malamou-Ladas, E. Nagy, Å Sullivan, C. E. Nord

Research output: Contribution to journalArticle

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Abstract

Gram-positive anaerobic cocci (GPAC) are a heterogeneous group of microorganisms frequently isolated from local and systemic infections. In this study, the antimicrobial susceptibilities of clinical strains isolated in 10 European countries were investigated. After identification of 299 GPAC to species level, the minimum inhibitory concentrations of penicillin, imipenem, clindamycin, metronidazole, vancomycin and linezolid were determined by the agar dilution method according to the Clinical and Laboratory Standards Institute. The majority of isolates were identified as Finegoldia magna and Parvimonas micra (formerly Peptostreptococcus micros), isolated from skin and soft tissue infections. All isolates were susceptible to imipenem, metronidazole, vancomycin and linezolid. Twenty-one isolates (7%) were resistant to penicillin (n = 13) and/or to clindamycin (n = 12). Four isolates were resistant to both agents. The majority of resistant isolates were identified as F. magna and originated from blood, abscesses and soft tissue infections.

Original languageEnglish
Pages (from-to)316-320
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume31
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Linezolid
Gram-Positive Cocci
Soft Tissue Infections
Clindamycin
Imipenem
Metronidazole
Vancomycin
Penicillins
Peptostreptococcus
Microbial Sensitivity Tests
Abscess
Agar
Skin
Infection

Keywords

  • Anaerobic cocci
  • Antimicrobial resistance
  • Clinical isolates

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

European surveillance study on antimicrobial susceptibility of Gram-positive anaerobic cocci. / Brazier, J.; Chmelar, D.; Dubreuil, L.; Feierl, G.; Hedberg, M.; Kalenic, S.; Könönen, E.; Lundgren, B.; Malamou-Ladas, H.; Nagy, E.; Sullivan, Å; Nord, C. E.

In: International Journal of Antimicrobial Agents, Vol. 31, No. 4, 04.2008, p. 316-320.

Research output: Contribution to journalArticle

Brazier, J, Chmelar, D, Dubreuil, L, Feierl, G, Hedberg, M, Kalenic, S, Könönen, E, Lundgren, B, Malamou-Ladas, H, Nagy, E, Sullivan, Å & Nord, CE 2008, 'European surveillance study on antimicrobial susceptibility of Gram-positive anaerobic cocci', International Journal of Antimicrobial Agents, vol. 31, no. 4, pp. 316-320. https://doi.org/10.1016/j.ijantimicag.2007.11.006
Brazier, J. ; Chmelar, D. ; Dubreuil, L. ; Feierl, G. ; Hedberg, M. ; Kalenic, S. ; Könönen, E. ; Lundgren, B. ; Malamou-Ladas, H. ; Nagy, E. ; Sullivan, Å ; Nord, C. E. / European surveillance study on antimicrobial susceptibility of Gram-positive anaerobic cocci. In: International Journal of Antimicrobial Agents. 2008 ; Vol. 31, No. 4. pp. 316-320.
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