European Surveillance of Antimicrobial Consumptionesac (ESAC): Outpatient penicillin use in Europe (1997-2009)

Ann Versporten, Samuel Coenen, Niels Adriaenssens, Arno Muller, Girma Minalu, Christel Faes, Vanessa Vankerckhoven, Marc Aerts, Niel Hens, Geert Molenberghs, Herman Goossens, Sigrid Metz, Gerhard Fluch, Sofie Vaerenberg, Mathijs Michiel Goossens, Boyka Markova, Arjana Tambic Andrašević, Antonis Kontemeniotis, Jiří Vlček, Niels Frimodt-MøllerUlrich Stab Jensen, Ly Rootslane, Ott Laius, Jaana Vuopio-Varkila, Outi Lyytikainen, Philippe Cavalie, Winfried Kern, Helen Giamarellou, Anastasia Antoniadou, G. Ternák, R. Benkó, Haraldur Briem, Olafur Einarsson, Robert Cunney, Ajay Oza, Raul Raz, Hana Edelstein, Pietro Folino, Andis Seilis, Uga Dumpis, Rolanda Valinteliene, Marcel Bruch, Michael Borg, Peter Zarb, Stephanie Natsch, Marieke Kwint, Hege Salvesen Blix, Waleria Hryniewics, Anna Olczak-Pienkowska, Malgorzata Kravanja, Tomasz Ozorowski, Mafalda Ribeirinho, Luis Caldeira, Anda Bǎicuş, Gabriel Popescu, Svetlana Ratchina, Roman Kozlov, Viliam Foltán, Milan Čižman, Edurne Lázaro, José Campos, Francisco de Abajo, Ulrica Dohnhammar, Giorgio Zanetti, Peter Davey, Hayley Wickens

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Data on 13 years (1997-2009) of outpatient penicillin use were collected from 33 European countries within the European Surveillance of Antimicrobial Consumption (ESAC) project and analysed in detail. Methods: For the period 1997-2009, data on outpatient use of systemic penicillins aggregated at the level of the active substance were collected using the Anatomical Therapeutic Chemical (ATC)/defined daily dose (DDD) method (WHO, version 2011) and expressed in DDD per 1000 inhabitants per day (DID). For detailed analysis of trends over time, seasonal variation and composition of outpatient penicillin use in 33 European countries, we distinguished between narrow-spectrum penicillins (NSP), broad-spectrum penicillins (BSP), penicillinase-resistant penicillins (PRP) and combinations with β-lactamase inhibitors (COP). Results: Total outpatient penicillin (ATC group J01C) use in 2009 varied by a factor of 3.8 between the countries with the highest (16.08 DID in France) and lowest (4.23 DID in the Russian Federation) use. COP represented 45.8%, BSP 40.7%, NSP 10.8% and PRP 2.6% of total European outpatient penicillin use. Total outpatient penicillin use significantly increased over time by 1.53 (SD 0.71) DID between 1997 and 2009. COP (mainly co-amoxiclav) increased by 2.17 (SD 0.40) DID, which was the result of its absolute increase as well as the observed shift from NSP and BSP towards COP. This increase exceeded 10% in 20 countries, where it coincided with a similar decrease in either BSP (15 countries) or NSP (5 countries). Conclusions: Penicillins represented the most widely used antibiotic subgroup in all 33 participating countries, albeit with considerable variation in their use patterns. For Europe, a continuous increase in overall penicillin use and of COP use was observed during the period 1997-2009.

Original languageEnglish
Article numberdkr454
JournalJournal of Antimicrobial Chemotherapy
Volume66
Issue numberSUPPL. 6
DOIs
Publication statusPublished - Dec 2011

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Penicillins
Outpatients
Penicillinase
Amoxicillin-Potassium Clavulanate Combination
France

Keywords

  • Ambulatory care
  • Antibiotic use
  • Co-amoxiclav
  • Pharmacoepidemiology

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Versporten, A., Coenen, S., Adriaenssens, N., Muller, A., Minalu, G., Faes, C., ... Wickens, H. (2011). European Surveillance of Antimicrobial Consumptionesac (ESAC): Outpatient penicillin use in Europe (1997-2009). Journal of Antimicrobial Chemotherapy, 66(SUPPL. 6), [dkr454]. https://doi.org/10.1093/jac/dkr454

European Surveillance of Antimicrobial Consumptionesac (ESAC) : Outpatient penicillin use in Europe (1997-2009). / Versporten, Ann; Coenen, Samuel; Adriaenssens, Niels; Muller, Arno; Minalu, Girma; Faes, Christel; Vankerckhoven, Vanessa; Aerts, Marc; Hens, Niel; Molenberghs, Geert; Goossens, Herman; Metz, Sigrid; Fluch, Gerhard; Vaerenberg, Sofie; Goossens, Mathijs Michiel; Markova, Boyka; Andrašević, Arjana Tambic; Kontemeniotis, Antonis; Vlček, Jiří; Frimodt-Møller, Niels; Jensen, Ulrich Stab; Rootslane, Ly; Laius, Ott; Vuopio-Varkila, Jaana; Lyytikainen, Outi; Cavalie, Philippe; Kern, Winfried; Giamarellou, Helen; Antoniadou, Anastasia; Ternák, G.; Benkó, R.; Briem, Haraldur; Einarsson, Olafur; Cunney, Robert; Oza, Ajay; Raz, Raul; Edelstein, Hana; Folino, Pietro; Seilis, Andis; Dumpis, Uga; Valinteliene, Rolanda; Bruch, Marcel; Borg, Michael; Zarb, Peter; Natsch, Stephanie; Kwint, Marieke; Blix, Hege Salvesen; Hryniewics, Waleria; Olczak-Pienkowska, Anna; Kravanja, Malgorzata; Ozorowski, Tomasz; Ribeirinho, Mafalda; Caldeira, Luis; Bǎicuş, Anda; Popescu, Gabriel; Ratchina, Svetlana; Kozlov, Roman; Foltán, Viliam; Čižman, Milan; Lázaro, Edurne; Campos, José; de Abajo, Francisco; Dohnhammar, Ulrica; Zanetti, Giorgio; Davey, Peter; Wickens, Hayley.

In: Journal of Antimicrobial Chemotherapy, Vol. 66, No. SUPPL. 6, dkr454, 12.2011.

Research output: Contribution to journalArticle

Versporten, A, Coenen, S, Adriaenssens, N, Muller, A, Minalu, G, Faes, C, Vankerckhoven, V, Aerts, M, Hens, N, Molenberghs, G, Goossens, H, Metz, S, Fluch, G, Vaerenberg, S, Goossens, MM, Markova, B, Andrašević, AT, Kontemeniotis, A, Vlček, J, Frimodt-Møller, N, Jensen, US, Rootslane, L, Laius, O, Vuopio-Varkila, J, Lyytikainen, O, Cavalie, P, Kern, W, Giamarellou, H, Antoniadou, A, Ternák, G, Benkó, R, Briem, H, Einarsson, O, Cunney, R, Oza, A, Raz, R, Edelstein, H, Folino, P, Seilis, A, Dumpis, U, Valinteliene, R, Bruch, M, Borg, M, Zarb, P, Natsch, S, Kwint, M, Blix, HS, Hryniewics, W, Olczak-Pienkowska, A, Kravanja, M, Ozorowski, T, Ribeirinho, M, Caldeira, L, Bǎicuş, A, Popescu, G, Ratchina, S, Kozlov, R, Foltán, V, Čižman, M, Lázaro, E, Campos, J, de Abajo, F, Dohnhammar, U, Zanetti, G, Davey, P & Wickens, H 2011, 'European Surveillance of Antimicrobial Consumptionesac (ESAC): Outpatient penicillin use in Europe (1997-2009)', Journal of Antimicrobial Chemotherapy, vol. 66, no. SUPPL. 6, dkr454. https://doi.org/10.1093/jac/dkr454
Versporten, Ann ; Coenen, Samuel ; Adriaenssens, Niels ; Muller, Arno ; Minalu, Girma ; Faes, Christel ; Vankerckhoven, Vanessa ; Aerts, Marc ; Hens, Niel ; Molenberghs, Geert ; Goossens, Herman ; Metz, Sigrid ; Fluch, Gerhard ; Vaerenberg, Sofie ; Goossens, Mathijs Michiel ; Markova, Boyka ; Andrašević, Arjana Tambic ; Kontemeniotis, Antonis ; Vlček, Jiří ; Frimodt-Møller, Niels ; Jensen, Ulrich Stab ; Rootslane, Ly ; Laius, Ott ; Vuopio-Varkila, Jaana ; Lyytikainen, Outi ; Cavalie, Philippe ; Kern, Winfried ; Giamarellou, Helen ; Antoniadou, Anastasia ; Ternák, G. ; Benkó, R. ; Briem, Haraldur ; Einarsson, Olafur ; Cunney, Robert ; Oza, Ajay ; Raz, Raul ; Edelstein, Hana ; Folino, Pietro ; Seilis, Andis ; Dumpis, Uga ; Valinteliene, Rolanda ; Bruch, Marcel ; Borg, Michael ; Zarb, Peter ; Natsch, Stephanie ; Kwint, Marieke ; Blix, Hege Salvesen ; Hryniewics, Waleria ; Olczak-Pienkowska, Anna ; Kravanja, Malgorzata ; Ozorowski, Tomasz ; Ribeirinho, Mafalda ; Caldeira, Luis ; Bǎicuş, Anda ; Popescu, Gabriel ; Ratchina, Svetlana ; Kozlov, Roman ; Foltán, Viliam ; Čižman, Milan ; Lázaro, Edurne ; Campos, José ; de Abajo, Francisco ; Dohnhammar, Ulrica ; Zanetti, Giorgio ; Davey, Peter ; Wickens, Hayley. / European Surveillance of Antimicrobial Consumptionesac (ESAC) : Outpatient penicillin use in Europe (1997-2009). In: Journal of Antimicrobial Chemotherapy. 2011 ; Vol. 66, No. SUPPL. 6.
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title = "European Surveillance of Antimicrobial Consumptionesac (ESAC): Outpatient penicillin use in Europe (1997-2009)",
abstract = "Background: Data on 13 years (1997-2009) of outpatient penicillin use were collected from 33 European countries within the European Surveillance of Antimicrobial Consumption (ESAC) project and analysed in detail. Methods: For the period 1997-2009, data on outpatient use of systemic penicillins aggregated at the level of the active substance were collected using the Anatomical Therapeutic Chemical (ATC)/defined daily dose (DDD) method (WHO, version 2011) and expressed in DDD per 1000 inhabitants per day (DID). For detailed analysis of trends over time, seasonal variation and composition of outpatient penicillin use in 33 European countries, we distinguished between narrow-spectrum penicillins (NSP), broad-spectrum penicillins (BSP), penicillinase-resistant penicillins (PRP) and combinations with β-lactamase inhibitors (COP). Results: Total outpatient penicillin (ATC group J01C) use in 2009 varied by a factor of 3.8 between the countries with the highest (16.08 DID in France) and lowest (4.23 DID in the Russian Federation) use. COP represented 45.8{\%}, BSP 40.7{\%}, NSP 10.8{\%} and PRP 2.6{\%} of total European outpatient penicillin use. Total outpatient penicillin use significantly increased over time by 1.53 (SD 0.71) DID between 1997 and 2009. COP (mainly co-amoxiclav) increased by 2.17 (SD 0.40) DID, which was the result of its absolute increase as well as the observed shift from NSP and BSP towards COP. This increase exceeded 10{\%} in 20 countries, where it coincided with a similar decrease in either BSP (15 countries) or NSP (5 countries). Conclusions: Penicillins represented the most widely used antibiotic subgroup in all 33 participating countries, albeit with considerable variation in their use patterns. For Europe, a continuous increase in overall penicillin use and of COP use was observed during the period 1997-2009.",
keywords = "Ambulatory care, Antibiotic use, Co-amoxiclav, Pharmacoepidemiology",
author = "Ann Versporten and Samuel Coenen and Niels Adriaenssens and Arno Muller and Girma Minalu and Christel Faes and Vanessa Vankerckhoven and Marc Aerts and Niel Hens and Geert Molenberghs and Herman Goossens and Sigrid Metz and Gerhard Fluch and Sofie Vaerenberg and Goossens, {Mathijs Michiel} and Boyka Markova and Andrašević, {Arjana Tambic} and Antonis Kontemeniotis and Jiř{\'i} Vlček and Niels Frimodt-M{\o}ller and Jensen, {Ulrich Stab} and Ly Rootslane and Ott Laius and Jaana Vuopio-Varkila and Outi Lyytikainen and Philippe Cavalie and Winfried Kern and Helen Giamarellou and Anastasia Antoniadou and G. Tern{\'a}k and R. Benk{\'o} and Haraldur Briem and Olafur Einarsson and Robert Cunney and Ajay Oza and Raul Raz and Hana Edelstein and Pietro Folino and Andis Seilis and Uga Dumpis and Rolanda Valinteliene and Marcel Bruch and Michael Borg and Peter Zarb and Stephanie Natsch and Marieke Kwint and Blix, {Hege Salvesen} and Waleria Hryniewics and Anna Olczak-Pienkowska and Malgorzata Kravanja and Tomasz Ozorowski and Mafalda Ribeirinho and Luis Caldeira and Anda Bǎicuş and Gabriel Popescu and Svetlana Ratchina and Roman Kozlov and Viliam Folt{\'a}n and Milan Čižman and Edurne L{\'a}zaro and Jos{\'e} Campos and {de Abajo}, Francisco and Ulrica Dohnhammar and Giorgio Zanetti and Peter Davey and Hayley Wickens",
year = "2011",
month = "12",
doi = "10.1093/jac/dkr454",
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journal = "Journal of Antimicrobial Chemotherapy",
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TY - JOUR

T1 - European Surveillance of Antimicrobial Consumptionesac (ESAC)

T2 - Outpatient penicillin use in Europe (1997-2009)

AU - Versporten, Ann

AU - Coenen, Samuel

AU - Adriaenssens, Niels

AU - Muller, Arno

AU - Minalu, Girma

AU - Faes, Christel

AU - Vankerckhoven, Vanessa

AU - Aerts, Marc

AU - Hens, Niel

AU - Molenberghs, Geert

AU - Goossens, Herman

AU - Metz, Sigrid

AU - Fluch, Gerhard

AU - Vaerenberg, Sofie

AU - Goossens, Mathijs Michiel

AU - Markova, Boyka

AU - Andrašević, Arjana Tambic

AU - Kontemeniotis, Antonis

AU - Vlček, Jiří

AU - Frimodt-Møller, Niels

AU - Jensen, Ulrich Stab

AU - Rootslane, Ly

AU - Laius, Ott

AU - Vuopio-Varkila, Jaana

AU - Lyytikainen, Outi

AU - Cavalie, Philippe

AU - Kern, Winfried

AU - Giamarellou, Helen

AU - Antoniadou, Anastasia

AU - Ternák, G.

AU - Benkó, R.

AU - Briem, Haraldur

AU - Einarsson, Olafur

AU - Cunney, Robert

AU - Oza, Ajay

AU - Raz, Raul

AU - Edelstein, Hana

AU - Folino, Pietro

AU - Seilis, Andis

AU - Dumpis, Uga

AU - Valinteliene, Rolanda

AU - Bruch, Marcel

AU - Borg, Michael

AU - Zarb, Peter

AU - Natsch, Stephanie

AU - Kwint, Marieke

AU - Blix, Hege Salvesen

AU - Hryniewics, Waleria

AU - Olczak-Pienkowska, Anna

AU - Kravanja, Malgorzata

AU - Ozorowski, Tomasz

AU - Ribeirinho, Mafalda

AU - Caldeira, Luis

AU - Bǎicuş, Anda

AU - Popescu, Gabriel

AU - Ratchina, Svetlana

AU - Kozlov, Roman

AU - Foltán, Viliam

AU - Čižman, Milan

AU - Lázaro, Edurne

AU - Campos, José

AU - de Abajo, Francisco

AU - Dohnhammar, Ulrica

AU - Zanetti, Giorgio

AU - Davey, Peter

AU - Wickens, Hayley

PY - 2011/12

Y1 - 2011/12

N2 - Background: Data on 13 years (1997-2009) of outpatient penicillin use were collected from 33 European countries within the European Surveillance of Antimicrobial Consumption (ESAC) project and analysed in detail. Methods: For the period 1997-2009, data on outpatient use of systemic penicillins aggregated at the level of the active substance were collected using the Anatomical Therapeutic Chemical (ATC)/defined daily dose (DDD) method (WHO, version 2011) and expressed in DDD per 1000 inhabitants per day (DID). For detailed analysis of trends over time, seasonal variation and composition of outpatient penicillin use in 33 European countries, we distinguished between narrow-spectrum penicillins (NSP), broad-spectrum penicillins (BSP), penicillinase-resistant penicillins (PRP) and combinations with β-lactamase inhibitors (COP). Results: Total outpatient penicillin (ATC group J01C) use in 2009 varied by a factor of 3.8 between the countries with the highest (16.08 DID in France) and lowest (4.23 DID in the Russian Federation) use. COP represented 45.8%, BSP 40.7%, NSP 10.8% and PRP 2.6% of total European outpatient penicillin use. Total outpatient penicillin use significantly increased over time by 1.53 (SD 0.71) DID between 1997 and 2009. COP (mainly co-amoxiclav) increased by 2.17 (SD 0.40) DID, which was the result of its absolute increase as well as the observed shift from NSP and BSP towards COP. This increase exceeded 10% in 20 countries, where it coincided with a similar decrease in either BSP (15 countries) or NSP (5 countries). Conclusions: Penicillins represented the most widely used antibiotic subgroup in all 33 participating countries, albeit with considerable variation in their use patterns. For Europe, a continuous increase in overall penicillin use and of COP use was observed during the period 1997-2009.

AB - Background: Data on 13 years (1997-2009) of outpatient penicillin use were collected from 33 European countries within the European Surveillance of Antimicrobial Consumption (ESAC) project and analysed in detail. Methods: For the period 1997-2009, data on outpatient use of systemic penicillins aggregated at the level of the active substance were collected using the Anatomical Therapeutic Chemical (ATC)/defined daily dose (DDD) method (WHO, version 2011) and expressed in DDD per 1000 inhabitants per day (DID). For detailed analysis of trends over time, seasonal variation and composition of outpatient penicillin use in 33 European countries, we distinguished between narrow-spectrum penicillins (NSP), broad-spectrum penicillins (BSP), penicillinase-resistant penicillins (PRP) and combinations with β-lactamase inhibitors (COP). Results: Total outpatient penicillin (ATC group J01C) use in 2009 varied by a factor of 3.8 between the countries with the highest (16.08 DID in France) and lowest (4.23 DID in the Russian Federation) use. COP represented 45.8%, BSP 40.7%, NSP 10.8% and PRP 2.6% of total European outpatient penicillin use. Total outpatient penicillin use significantly increased over time by 1.53 (SD 0.71) DID between 1997 and 2009. COP (mainly co-amoxiclav) increased by 2.17 (SD 0.40) DID, which was the result of its absolute increase as well as the observed shift from NSP and BSP towards COP. This increase exceeded 10% in 20 countries, where it coincided with a similar decrease in either BSP (15 countries) or NSP (5 countries). Conclusions: Penicillins represented the most widely used antibiotic subgroup in all 33 participating countries, albeit with considerable variation in their use patterns. For Europe, a continuous increase in overall penicillin use and of COP use was observed during the period 1997-2009.

KW - Ambulatory care

KW - Antibiotic use

KW - Co-amoxiclav

KW - Pharmacoepidemiology

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