European Surveillance of Antimicrobial Consumption (ESAC): Outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe (1997-2009)

Samuel Coenen, Niels Adriaenssens, Ann Versporten, Arno Muller, Girma Minalu, Christel Faes, Vanessa Vankerckhoven, Marc Aerts, Niel Hens, Geert Molenberghs, Herman Goossens, Sigrid Metz, Gerhard Fluch, Sofie Vaerenberg, Mathijs Michiel Goossens, Boyka Markova, Arjana Tambic Andrašević, Antonis Kontemeniotis, Jiří Vlček, Niels Frimodt-MøllerUlrich Stab Jensen, Ly Rootslane, Ott Laius, Jaana Vuopio-Varkila, Outi Lyytikainen, Philippe Cavalie, Winfried Kern, Helen Giamarellou, Anastasia Antoniadou, G. Ternák, R. Benkó, Haraldur Briem, Olafur Einarsson, Robert Cunney, Ajay Oza, Raul Raz, Hana Edelstein, Pietro Folino, Andis Seilis, Uga Dumpis, Rolanda Valinteliene, Marcel Bruch, Michael Borg, Peter Zarb, Stephanie Natsch, Marieke Kwint, Hege Salvesen Blix, Waleria Hryniewics, Anna Olczak-Pienkowska, Malgorzata Kravanja, Tomasz Ozorowski, Mafalda Ribeirinho, Luis Caldeira, Anda Bǎicuş, Gabriel Popescu, Svetlana Ratchina, Roman Kozlov, Viliam Foltán, Milan Čižman, Edurne Lázaro, José Campos, Francisco de Abajo, Ulrica Dohnhammar, Giorgio Zanetti, Peter Davey, Hayley Wickens

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Data on more than a decade of outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe were collected from 33 countries as part of the European Surveillance of Antimicrobial Consumption (ESAC) project, funded by the European Centre for Disease Prevention and Control (ECDC). Methods: For the period 1997-2009, data on outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials aggregated at the level of the active substance were collected and expressed in defined daily doses (DDD; WHO, version 2011) per 1000 inhabitants per day (DID). Using the Anatomical Therapeutic Chemical (ATC) classification, trends in the use of tetracyclines (J01A), sulphonamides and trimethoprim (J01E) and other antibacterials (J01X) over time, seasonal variation and composition of use were analysed. Results: In 2009, the variations in outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials between countries, and also in the composition of use over time, were huge. For tetracyclines a significant and for sulphonamides and trimethoprim a non-significant decrease in use was observed between 1997 and 2009 in Europe. The seasonal variation in their use significantly decreased over time. For the other antibacterials, no significant changes in the volume of use or its seasonal variation were seen. Conclusions: As for all other major antibiotic subgroups, a striking variation in use and composition of use between countries in Europe was observed for outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials. In combination with the decreasing use, especially of recommended substances, this represents an opportunity not only to reduce antibiotic use but also to improve its quality.

Original languageEnglish
Article numberdkr458
JournalJournal of Antimicrobial Chemotherapy
Volume66
Issue numberSUPPL. 6
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Tetracyclines
Trimethoprim
Sulfonamides
Outpatients
Anti-Bacterial Agents
Dichlorodiphenyldichloroethane
Centers for Disease Control and Prevention (U.S.)

Keywords

  • Ambulatory care
  • Antibiotic use
  • Drug consumption
  • Pharmacoepidemiology
  • Urinary antiseptics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

European Surveillance of Antimicrobial Consumption (ESAC) : Outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe (1997-2009). / Coenen, Samuel; Adriaenssens, Niels; Versporten, Ann; Muller, Arno; Minalu, Girma; Faes, Christel; Vankerckhoven, Vanessa; Aerts, Marc; Hens, Niel; Molenberghs, Geert; Goossens, Herman; Metz, Sigrid; Fluch, Gerhard; Vaerenberg, Sofie; Goossens, Mathijs Michiel; Markova, Boyka; Andrašević, Arjana Tambic; Kontemeniotis, Antonis; Vlček, Jiří; Frimodt-Møller, Niels; Jensen, Ulrich Stab; Rootslane, Ly; Laius, Ott; Vuopio-Varkila, Jaana; Lyytikainen, Outi; Cavalie, Philippe; Kern, Winfried; Giamarellou, Helen; Antoniadou, Anastasia; Ternák, G.; Benkó, R.; Briem, Haraldur; Einarsson, Olafur; Cunney, Robert; Oza, Ajay; Raz, Raul; Edelstein, Hana; Folino, Pietro; Seilis, Andis; Dumpis, Uga; Valinteliene, Rolanda; Bruch, Marcel; Borg, Michael; Zarb, Peter; Natsch, Stephanie; Kwint, Marieke; Blix, Hege Salvesen; Hryniewics, Waleria; Olczak-Pienkowska, Anna; Kravanja, Malgorzata; Ozorowski, Tomasz; Ribeirinho, Mafalda; Caldeira, Luis; Bǎicuş, Anda; Popescu, Gabriel; Ratchina, Svetlana; Kozlov, Roman; Foltán, Viliam; Čižman, Milan; Lázaro, Edurne; Campos, José; de Abajo, Francisco; Dohnhammar, Ulrica; Zanetti, Giorgio; Davey, Peter; Wickens, Hayley.

In: Journal of Antimicrobial Chemotherapy, Vol. 66, No. SUPPL. 6, dkr458, 12.2011.

Research output: Contribution to journalArticle

Coenen, S, Adriaenssens, N, Versporten, A, Muller, A, Minalu, G, Faes, C, Vankerckhoven, V, Aerts, M, Hens, N, Molenberghs, G, Goossens, H, Metz, S, Fluch, G, Vaerenberg, S, Goossens, MM, Markova, B, Andrašević, AT, Kontemeniotis, A, Vlček, J, Frimodt-Møller, N, Jensen, US, Rootslane, L, Laius, O, Vuopio-Varkila, J, Lyytikainen, O, Cavalie, P, Kern, W, Giamarellou, H, Antoniadou, A, Ternák, G, Benkó, R, Briem, H, Einarsson, O, Cunney, R, Oza, A, Raz, R, Edelstein, H, Folino, P, Seilis, A, Dumpis, U, Valinteliene, R, Bruch, M, Borg, M, Zarb, P, Natsch, S, Kwint, M, Blix, HS, Hryniewics, W, Olczak-Pienkowska, A, Kravanja, M, Ozorowski, T, Ribeirinho, M, Caldeira, L, Bǎicuş, A, Popescu, G, Ratchina, S, Kozlov, R, Foltán, V, Čižman, M, Lázaro, E, Campos, J, de Abajo, F, Dohnhammar, U, Zanetti, G, Davey, P & Wickens, H 2011, 'European Surveillance of Antimicrobial Consumption (ESAC): Outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe (1997-2009)', Journal of Antimicrobial Chemotherapy, vol. 66, no. SUPPL. 6, dkr458. https://doi.org/10.1093/jac/dkr458
Coenen, Samuel ; Adriaenssens, Niels ; Versporten, Ann ; Muller, Arno ; Minalu, Girma ; Faes, Christel ; Vankerckhoven, Vanessa ; Aerts, Marc ; Hens, Niel ; Molenberghs, Geert ; Goossens, Herman ; Metz, Sigrid ; Fluch, Gerhard ; Vaerenberg, Sofie ; Goossens, Mathijs Michiel ; Markova, Boyka ; Andrašević, Arjana Tambic ; Kontemeniotis, Antonis ; Vlček, Jiří ; Frimodt-Møller, Niels ; Jensen, Ulrich Stab ; Rootslane, Ly ; Laius, Ott ; Vuopio-Varkila, Jaana ; Lyytikainen, Outi ; Cavalie, Philippe ; Kern, Winfried ; Giamarellou, Helen ; Antoniadou, Anastasia ; Ternák, G. ; Benkó, R. ; Briem, Haraldur ; Einarsson, Olafur ; Cunney, Robert ; Oza, Ajay ; Raz, Raul ; Edelstein, Hana ; Folino, Pietro ; Seilis, Andis ; Dumpis, Uga ; Valinteliene, Rolanda ; Bruch, Marcel ; Borg, Michael ; Zarb, Peter ; Natsch, Stephanie ; Kwint, Marieke ; Blix, Hege Salvesen ; Hryniewics, Waleria ; Olczak-Pienkowska, Anna ; Kravanja, Malgorzata ; Ozorowski, Tomasz ; Ribeirinho, Mafalda ; Caldeira, Luis ; Bǎicuş, Anda ; Popescu, Gabriel ; Ratchina, Svetlana ; Kozlov, Roman ; Foltán, Viliam ; Čižman, Milan ; Lázaro, Edurne ; Campos, José ; de Abajo, Francisco ; Dohnhammar, Ulrica ; Zanetti, Giorgio ; Davey, Peter ; Wickens, Hayley. / European Surveillance of Antimicrobial Consumption (ESAC) : Outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe (1997-2009). In: Journal of Antimicrobial Chemotherapy. 2011 ; Vol. 66, No. SUPPL. 6.
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abstract = "Background: Data on more than a decade of outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe were collected from 33 countries as part of the European Surveillance of Antimicrobial Consumption (ESAC) project, funded by the European Centre for Disease Prevention and Control (ECDC). Methods: For the period 1997-2009, data on outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials aggregated at the level of the active substance were collected and expressed in defined daily doses (DDD; WHO, version 2011) per 1000 inhabitants per day (DID). Using the Anatomical Therapeutic Chemical (ATC) classification, trends in the use of tetracyclines (J01A), sulphonamides and trimethoprim (J01E) and other antibacterials (J01X) over time, seasonal variation and composition of use were analysed. Results: In 2009, the variations in outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials between countries, and also in the composition of use over time, were huge. For tetracyclines a significant and for sulphonamides and trimethoprim a non-significant decrease in use was observed between 1997 and 2009 in Europe. The seasonal variation in their use significantly decreased over time. For the other antibacterials, no significant changes in the volume of use or its seasonal variation were seen. Conclusions: As for all other major antibiotic subgroups, a striking variation in use and composition of use between countries in Europe was observed for outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials. In combination with the decreasing use, especially of recommended substances, this represents an opportunity not only to reduce antibiotic use but also to improve its quality.",
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T1 - European Surveillance of Antimicrobial Consumption (ESAC)

T2 - Outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe (1997-2009)

AU - Coenen, Samuel

AU - Adriaenssens, Niels

AU - Versporten, Ann

AU - Muller, Arno

AU - Minalu, Girma

AU - Faes, Christel

AU - Vankerckhoven, Vanessa

AU - Aerts, Marc

AU - Hens, Niel

AU - Molenberghs, Geert

AU - Goossens, Herman

AU - Metz, Sigrid

AU - Fluch, Gerhard

AU - Vaerenberg, Sofie

AU - Goossens, Mathijs Michiel

AU - Markova, Boyka

AU - Andrašević, Arjana Tambic

AU - Kontemeniotis, Antonis

AU - Vlček, Jiří

AU - Frimodt-Møller, Niels

AU - Jensen, Ulrich Stab

AU - Rootslane, Ly

AU - Laius, Ott

AU - Vuopio-Varkila, Jaana

AU - Lyytikainen, Outi

AU - Cavalie, Philippe

AU - Kern, Winfried

AU - Giamarellou, Helen

AU - Antoniadou, Anastasia

AU - Ternák, G.

AU - Benkó, R.

AU - Briem, Haraldur

AU - Einarsson, Olafur

AU - Cunney, Robert

AU - Oza, Ajay

AU - Raz, Raul

AU - Edelstein, Hana

AU - Folino, Pietro

AU - Seilis, Andis

AU - Dumpis, Uga

AU - Valinteliene, Rolanda

AU - Bruch, Marcel

AU - Borg, Michael

AU - Zarb, Peter

AU - Natsch, Stephanie

AU - Kwint, Marieke

AU - Blix, Hege Salvesen

AU - Hryniewics, Waleria

AU - Olczak-Pienkowska, Anna

AU - Kravanja, Malgorzata

AU - Ozorowski, Tomasz

AU - Ribeirinho, Mafalda

AU - Caldeira, Luis

AU - Bǎicuş, Anda

AU - Popescu, Gabriel

AU - Ratchina, Svetlana

AU - Kozlov, Roman

AU - Foltán, Viliam

AU - Čižman, Milan

AU - Lázaro, Edurne

AU - Campos, José

AU - de Abajo, Francisco

AU - Dohnhammar, Ulrica

AU - Zanetti, Giorgio

AU - Davey, Peter

AU - Wickens, Hayley

PY - 2011/12

Y1 - 2011/12

N2 - Background: Data on more than a decade of outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe were collected from 33 countries as part of the European Surveillance of Antimicrobial Consumption (ESAC) project, funded by the European Centre for Disease Prevention and Control (ECDC). Methods: For the period 1997-2009, data on outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials aggregated at the level of the active substance were collected and expressed in defined daily doses (DDD; WHO, version 2011) per 1000 inhabitants per day (DID). Using the Anatomical Therapeutic Chemical (ATC) classification, trends in the use of tetracyclines (J01A), sulphonamides and trimethoprim (J01E) and other antibacterials (J01X) over time, seasonal variation and composition of use were analysed. Results: In 2009, the variations in outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials between countries, and also in the composition of use over time, were huge. For tetracyclines a significant and for sulphonamides and trimethoprim a non-significant decrease in use was observed between 1997 and 2009 in Europe. The seasonal variation in their use significantly decreased over time. For the other antibacterials, no significant changes in the volume of use or its seasonal variation were seen. Conclusions: As for all other major antibiotic subgroups, a striking variation in use and composition of use between countries in Europe was observed for outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials. In combination with the decreasing use, especially of recommended substances, this represents an opportunity not only to reduce antibiotic use but also to improve its quality.

AB - Background: Data on more than a decade of outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe were collected from 33 countries as part of the European Surveillance of Antimicrobial Consumption (ESAC) project, funded by the European Centre for Disease Prevention and Control (ECDC). Methods: For the period 1997-2009, data on outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials aggregated at the level of the active substance were collected and expressed in defined daily doses (DDD; WHO, version 2011) per 1000 inhabitants per day (DID). Using the Anatomical Therapeutic Chemical (ATC) classification, trends in the use of tetracyclines (J01A), sulphonamides and trimethoprim (J01E) and other antibacterials (J01X) over time, seasonal variation and composition of use were analysed. Results: In 2009, the variations in outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials between countries, and also in the composition of use over time, were huge. For tetracyclines a significant and for sulphonamides and trimethoprim a non-significant decrease in use was observed between 1997 and 2009 in Europe. The seasonal variation in their use significantly decreased over time. For the other antibacterials, no significant changes in the volume of use or its seasonal variation were seen. Conclusions: As for all other major antibiotic subgroups, a striking variation in use and composition of use between countries in Europe was observed for outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials. In combination with the decreasing use, especially of recommended substances, this represents an opportunity not only to reduce antibiotic use but also to improve its quality.

KW - Ambulatory care

KW - Antibiotic use

KW - Drug consumption

KW - Pharmacoepidemiology

KW - Urinary antiseptics

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