European surveillance for pantropic canine coronavirus

Nicola Decaro, Nathalie Cordonnier, Zoltan Demeter, Herman Egberink, Gabriella Elia, Aurélien Grellet, Sophie Le Poder, Viviana Mari, Vito Martella, Vasileios Ntafis, Marcela Von Reitzenstein, Peter J. Rottier, Miklos Rusvai, Shelly Shields, Eftychia Xylouri, Zach Xu, Canio Buonavoglia

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25 Citations (Scopus)


Highly virulent pantropic canine coronavirus (CCoV) strains belonging to subtype IIa were recently identified in dogs. To assess the distribution of such strains in Europe, tissue samples were collected from 354 dogs that had died after displaying systemic disease in France (n = 92), Hungary (n = 75), Italy (n = 69), Greece (n = 87), The Netherlands (n = 27), Belgium (n = 4), and Bulgaria (n = 1). A total of 124 animals tested positive for CCoV, with 33 of them displaying the virus in extraintestinal tissues. Twenty-four CCoV strains (19.35% of the CCoV-positive dogs) detected in internal organs were characterized as subtype IIa and consequently assumed to be pantropic CCoVs. Sequence and phylogenetic analyses of the 5′ end of the spike protein gene showed that pantropic CCoV strains are closely related to each other, with the exception of two divergent French viruses that clustered with enteric strains.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalJournal of Clinical Microbiology
Issue number1
Publication statusPublished - Jan 2013

ASJC Scopus subject areas

  • Microbiology (medical)

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    Decaro, N., Cordonnier, N., Demeter, Z., Egberink, H., Elia, G., Grellet, A., Poder, S. L., Mari, V., Martella, V., Ntafis, V., Von Reitzenstein, M., Rottier, P. J., Rusvai, M., Shields, S., Xylouri, E., Xu, Z., & Buonavoglia, C. (2013). European surveillance for pantropic canine coronavirus. Journal of Clinical Microbiology, 51(1), 83-88.