European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I

Susanne Krege, Jörg Beyer, Rainer Souchon, Peter Albers, Walter Albrecht, Ferran Algaba, Michael Bamberg, I. Bodrogi, Carsten Bokemeyer, Eva Cavallin-Ståhl, Johannes Classen, Christoph Clemm, Gabriella Cohn-Cedermark, Stéphane Culine, Gedske Daugaard, Pieter H M De Mulder, Maria De Santis, Maike de Wit, Ronald de Wit, Hans Günter DerigsKlaus Peter Dieckmann, Annette Dieing, Jean Pierre Droz, Martin Fenner, Karim Fizazi, Aude Flechon, Sophie D. Fosså, Xavier Garcia del Muro, Thomas Gauler, L. Géczi, Arthur Gerl, Jose Ramon Germa-Lluch, Silke Gillessen, Jörg T. Hartmann, Michael Hartmann, Axel Heidenreich, Wolfgang Hoeltl, Alan Horwich, Robert Huddart, Michael Jewett, Johnathan Joffe, William G. Jones, László Kisbenedek, Olbjørn Klepp, Sabine Kliesch, Kai Uwe Koehrmann, Christian Kollmannsberger, Markus Kuczyk, Pilar Laguna, Oscar Leiva Galvis, Volker Loy, Malcolm D. Mason, Graham M. Mead, Rolf Mueller, Craig Nichols, Nicola Nicolai, Tim Oliver, Dalibor Ondrus, Gosse O N Oosterhof, Luis Paz Ares, Giorgio Pizzocaro, Jörg Pont, Tobias Pottek, Tom Powles, Oliver Rick, Giovanni Rosti, Roberto Salvioni, Jutta Scheiderbauer, Hans Ulrich Schmelz, Heinz Schmidberger, Hans Joachim Schmoll, Mark Schrader, Felix Sedlmayer, Niels E. Skakkebaek, Aslam Sohaib, Sergei Tjulandin, Padraig Warde, Stefan Weinknecht, Lothar Weissbach, Christian Wittekind, Eva Winter, Lori Wood, Hans von der Maase

Research output: Contribution to journalArticle

365 Citations (Scopus)

Abstract

Objectives: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. Methods: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged.

Original languageEnglish
Pages (from-to)478-496
Number of pages19
JournalEuropean Urology
Volume53
Issue number3
DOIs
Publication statusPublished - Mar 2008

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Germ Cell and Embryonal Neoplasms
Testicular Neoplasms
Seminoma
Clinical Competence
Evidence-Based Medicine
Urology
Therapeutics
Netherlands
Survivors
Neoplasms
Clinical Trials
Guidelines

Keywords

  • Diagnostics in testicular cancer
  • Treatment in non-seminoma CSI
  • Treatment in seminoma CSI

ASJC Scopus subject areas

  • Urology

Cite this

European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer : A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I. / Krege, Susanne; Beyer, Jörg; Souchon, Rainer; Albers, Peter; Albrecht, Walter; Algaba, Ferran; Bamberg, Michael; Bodrogi, I.; Bokemeyer, Carsten; Cavallin-Ståhl, Eva; Classen, Johannes; Clemm, Christoph; Cohn-Cedermark, Gabriella; Culine, Stéphane; Daugaard, Gedske; De Mulder, Pieter H M; De Santis, Maria; de Wit, Maike; de Wit, Ronald; Derigs, Hans Günter; Dieckmann, Klaus Peter; Dieing, Annette; Droz, Jean Pierre; Fenner, Martin; Fizazi, Karim; Flechon, Aude; Fosså, Sophie D.; Garcia del Muro, Xavier; Gauler, Thomas; Géczi, L.; Gerl, Arthur; Germa-Lluch, Jose Ramon; Gillessen, Silke; Hartmann, Jörg T.; Hartmann, Michael; Heidenreich, Axel; Hoeltl, Wolfgang; Horwich, Alan; Huddart, Robert; Jewett, Michael; Joffe, Johnathan; Jones, William G.; Kisbenedek, László; Klepp, Olbjørn; Kliesch, Sabine; Koehrmann, Kai Uwe; Kollmannsberger, Christian; Kuczyk, Markus; Laguna, Pilar; Leiva Galvis, Oscar; Loy, Volker; Mason, Malcolm D.; Mead, Graham M.; Mueller, Rolf; Nichols, Craig; Nicolai, Nicola; Oliver, Tim; Ondrus, Dalibor; Oosterhof, Gosse O N; Paz Ares, Luis; Pizzocaro, Giorgio; Pont, Jörg; Pottek, Tobias; Powles, Tom; Rick, Oliver; Rosti, Giovanni; Salvioni, Roberto; Scheiderbauer, Jutta; Schmelz, Hans Ulrich; Schmidberger, Heinz; Schmoll, Hans Joachim; Schrader, Mark; Sedlmayer, Felix; Skakkebaek, Niels E.; Sohaib, Aslam; Tjulandin, Sergei; Warde, Padraig; Weinknecht, Stefan; Weissbach, Lothar; Wittekind, Christian; Winter, Eva; Wood, Lori; von der Maase, Hans.

In: European Urology, Vol. 53, No. 3, 03.2008, p. 478-496.

Research output: Contribution to journalArticle

Krege, S, Beyer, J, Souchon, R, Albers, P, Albrecht, W, Algaba, F, Bamberg, M, Bodrogi, I, Bokemeyer, C, Cavallin-Ståhl, E, Classen, J, Clemm, C, Cohn-Cedermark, G, Culine, S, Daugaard, G, De Mulder, PHM, De Santis, M, de Wit, M, de Wit, R, Derigs, HG, Dieckmann, KP, Dieing, A, Droz, JP, Fenner, M, Fizazi, K, Flechon, A, Fosså, SD, Garcia del Muro, X, Gauler, T, Géczi, L, Gerl, A, Germa-Lluch, JR, Gillessen, S, Hartmann, JT, Hartmann, M, Heidenreich, A, Hoeltl, W, Horwich, A, Huddart, R, Jewett, M, Joffe, J, Jones, WG, Kisbenedek, L, Klepp, O, Kliesch, S, Koehrmann, KU, Kollmannsberger, C, Kuczyk, M, Laguna, P, Leiva Galvis, O, Loy, V, Mason, MD, Mead, GM, Mueller, R, Nichols, C, Nicolai, N, Oliver, T, Ondrus, D, Oosterhof, GON, Paz Ares, L, Pizzocaro, G, Pont, J, Pottek, T, Powles, T, Rick, O, Rosti, G, Salvioni, R, Scheiderbauer, J, Schmelz, HU, Schmidberger, H, Schmoll, HJ, Schrader, M, Sedlmayer, F, Skakkebaek, NE, Sohaib, A, Tjulandin, S, Warde, P, Weinknecht, S, Weissbach, L, Wittekind, C, Winter, E, Wood, L & von der Maase, H 2008, 'European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I', European Urology, vol. 53, no. 3, pp. 478-496. https://doi.org/10.1016/j.eururo.2007.12.024
Krege, Susanne ; Beyer, Jörg ; Souchon, Rainer ; Albers, Peter ; Albrecht, Walter ; Algaba, Ferran ; Bamberg, Michael ; Bodrogi, I. ; Bokemeyer, Carsten ; Cavallin-Ståhl, Eva ; Classen, Johannes ; Clemm, Christoph ; Cohn-Cedermark, Gabriella ; Culine, Stéphane ; Daugaard, Gedske ; De Mulder, Pieter H M ; De Santis, Maria ; de Wit, Maike ; de Wit, Ronald ; Derigs, Hans Günter ; Dieckmann, Klaus Peter ; Dieing, Annette ; Droz, Jean Pierre ; Fenner, Martin ; Fizazi, Karim ; Flechon, Aude ; Fosså, Sophie D. ; Garcia del Muro, Xavier ; Gauler, Thomas ; Géczi, L. ; Gerl, Arthur ; Germa-Lluch, Jose Ramon ; Gillessen, Silke ; Hartmann, Jörg T. ; Hartmann, Michael ; Heidenreich, Axel ; Hoeltl, Wolfgang ; Horwich, Alan ; Huddart, Robert ; Jewett, Michael ; Joffe, Johnathan ; Jones, William G. ; Kisbenedek, László ; Klepp, Olbjørn ; Kliesch, Sabine ; Koehrmann, Kai Uwe ; Kollmannsberger, Christian ; Kuczyk, Markus ; Laguna, Pilar ; Leiva Galvis, Oscar ; Loy, Volker ; Mason, Malcolm D. ; Mead, Graham M. ; Mueller, Rolf ; Nichols, Craig ; Nicolai, Nicola ; Oliver, Tim ; Ondrus, Dalibor ; Oosterhof, Gosse O N ; Paz Ares, Luis ; Pizzocaro, Giorgio ; Pont, Jörg ; Pottek, Tobias ; Powles, Tom ; Rick, Oliver ; Rosti, Giovanni ; Salvioni, Roberto ; Scheiderbauer, Jutta ; Schmelz, Hans Ulrich ; Schmidberger, Heinz ; Schmoll, Hans Joachim ; Schrader, Mark ; Sedlmayer, Felix ; Skakkebaek, Niels E. ; Sohaib, Aslam ; Tjulandin, Sergei ; Warde, Padraig ; Weinknecht, Stefan ; Weissbach, Lothar ; Wittekind, Christian ; Winter, Eva ; Wood, Lori ; von der Maase, Hans. / European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer : A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I. In: European Urology. 2008 ; Vol. 53, No. 3. pp. 478-496.
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title = "European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I",
abstract = "Objectives: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. Methods: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged.",
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TY - JOUR

T1 - European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer

T2 - A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I

AU - Krege, Susanne

AU - Beyer, Jörg

AU - Souchon, Rainer

AU - Albers, Peter

AU - Albrecht, Walter

AU - Algaba, Ferran

AU - Bamberg, Michael

AU - Bodrogi, I.

AU - Bokemeyer, Carsten

AU - Cavallin-Ståhl, Eva

AU - Classen, Johannes

AU - Clemm, Christoph

AU - Cohn-Cedermark, Gabriella

AU - Culine, Stéphane

AU - Daugaard, Gedske

AU - De Mulder, Pieter H M

AU - De Santis, Maria

AU - de Wit, Maike

AU - de Wit, Ronald

AU - Derigs, Hans Günter

AU - Dieckmann, Klaus Peter

AU - Dieing, Annette

AU - Droz, Jean Pierre

AU - Fenner, Martin

AU - Fizazi, Karim

AU - Flechon, Aude

AU - Fosså, Sophie D.

AU - Garcia del Muro, Xavier

AU - Gauler, Thomas

AU - Géczi, L.

AU - Gerl, Arthur

AU - Germa-Lluch, Jose Ramon

AU - Gillessen, Silke

AU - Hartmann, Jörg T.

AU - Hartmann, Michael

AU - Heidenreich, Axel

AU - Hoeltl, Wolfgang

AU - Horwich, Alan

AU - Huddart, Robert

AU - Jewett, Michael

AU - Joffe, Johnathan

AU - Jones, William G.

AU - Kisbenedek, László

AU - Klepp, Olbjørn

AU - Kliesch, Sabine

AU - Koehrmann, Kai Uwe

AU - Kollmannsberger, Christian

AU - Kuczyk, Markus

AU - Laguna, Pilar

AU - Leiva Galvis, Oscar

AU - Loy, Volker

AU - Mason, Malcolm D.

AU - Mead, Graham M.

AU - Mueller, Rolf

AU - Nichols, Craig

AU - Nicolai, Nicola

AU - Oliver, Tim

AU - Ondrus, Dalibor

AU - Oosterhof, Gosse O N

AU - Paz Ares, Luis

AU - Pizzocaro, Giorgio

AU - Pont, Jörg

AU - Pottek, Tobias

AU - Powles, Tom

AU - Rick, Oliver

AU - Rosti, Giovanni

AU - Salvioni, Roberto

AU - Scheiderbauer, Jutta

AU - Schmelz, Hans Ulrich

AU - Schmidberger, Heinz

AU - Schmoll, Hans Joachim

AU - Schrader, Mark

AU - Sedlmayer, Felix

AU - Skakkebaek, Niels E.

AU - Sohaib, Aslam

AU - Tjulandin, Sergei

AU - Warde, Padraig

AU - Weinknecht, Stefan

AU - Weissbach, Lothar

AU - Wittekind, Christian

AU - Winter, Eva

AU - Wood, Lori

AU - von der Maase, Hans

PY - 2008/3

Y1 - 2008/3

N2 - Objectives: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. Methods: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged.

AB - Objectives: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. Methods: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged.

KW - Diagnostics in testicular cancer

KW - Treatment in non-seminoma CSI

KW - Treatment in seminoma CSI

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