Euphorbia and Momordica metabolites for overcoming multidrug resistance

Maria José U Ferreira, Noélia Duarte, Mariana Reis, Ana Margarida Madureira, J. Molnár

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Multidrug resistance (MDR) is the major obstacle for cancer chemotherapy. MDR is a multifactorial phenomenon that can result from several mechanisms, including an increased drug efflux, due to overexpression of P-glycoprotein (P-gp) that transports anticancer drugs out of the cells. Thus, the role of this transporter has made it a therapeutic target and the development of P-gp modulators considered among the most realistic approaches for overcoming P-gp-mediated MDR. Many other strategies have been proposed. One of them is the identification of compounds that selectively kill multidrug resistant cells. In our search for MDR modulators from plants, the P-gp inhibition ability of a large number of compounds on resistant cancer cells was evaluated. These compounds, presented in this review, comprise mainly diterpenes, triterpenes and phenolic derivatives. The most relevant results were obtained from two sets of compounds: macrocyclic diterpenes with the jatrophane and lathyrane scaffold, and triterpenes of the cucurbitane-type isolated from Euphorbia species and Momordica balsamina L., respectively. Additionally, some of those macrocyclic diterpenes, and ent-abietane diterpenic lactones, also isolated from Euphorbia species, were found to be selectively toxic to drug-resistant phenotypes.

Original languageEnglish
Pages (from-to)915-935
Number of pages21
JournalPhytochemistry Reviews
Volume13
Issue number4
DOIs
Publication statusPublished - Nov 9 2014

Fingerprint

Momordica
Euphorbia
multiple drug resistance
Multiple Drug Resistance
P-Glycoprotein
diterpenoids
metabolites
Triterpenes
Diterpenes
triterpenoids
Macrocyclic Compounds
Abietane Diterpenes
Pharmaceutical Preparations
drugs
antineoplastic agents
Poisons
Lactones
lactones
drug therapy
transporters

Keywords

  • ent-Abietane lactones
  • Euphorbia
  • Macrocyclic diterpenes
  • Momordica balsamina L
  • P-glycoprotein
  • Triterpenes

ASJC Scopus subject areas

  • Plant Science
  • Biotechnology

Cite this

Euphorbia and Momordica metabolites for overcoming multidrug resistance. / Ferreira, Maria José U; Duarte, Noélia; Reis, Mariana; Madureira, Ana Margarida; Molnár, J.

In: Phytochemistry Reviews, Vol. 13, No. 4, 09.11.2014, p. 915-935.

Research output: Contribution to journalArticle

Ferreira, Maria José U ; Duarte, Noélia ; Reis, Mariana ; Madureira, Ana Margarida ; Molnár, J. / Euphorbia and Momordica metabolites for overcoming multidrug resistance. In: Phytochemistry Reviews. 2014 ; Vol. 13, No. 4. pp. 915-935.
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