Etodolac and solid dispersion with β-cyclodextrin

J. Milić-Aškrabić, D. S. Rajić, Lj Tasić, S. Djurić, P. Kása, K. Pintye-Hódi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Etodolac/β-cyclodextrin (Eto/β-CD) dispersions were prepared with a view to study the influence of P-CD On the Solubility and dissolution rate of this poorly soluble drug. Two systems were used: physical mixture of Eto/β-CD and kneading solid dispersion of Eto/β-CD. Physical characterization of the prepared systems was carried out by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), x-ray, and IR studies. The solubility and dissolution rate of Eto were increased with β-CD physical mixture as well as with Eto/β-CD kneading solid dispersion. However, enhancement was not statistically different among various cyclodextrin dispersions.

Original languageEnglish
Pages (from-to)1123-1129
Number of pages7
JournalDrug Development and Industrial Pharmacy
Volume23
Issue number11
Publication statusPublished - 1997

Fingerprint

Etodolac
Cyclodextrins
Dispersions
Solubility
Dissolution
Differential Scanning Calorimetry
Electron Scanning Microscopy
Differential scanning calorimetry
X-Rays
X rays
Scanning electron microscopy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Milić-Aškrabić, J., Rajić, D. S., Tasić, L., Djurić, S., Kása, P., & Pintye-Hódi, K. (1997). Etodolac and solid dispersion with β-cyclodextrin. Drug Development and Industrial Pharmacy, 23(11), 1123-1129.

Etodolac and solid dispersion with β-cyclodextrin. / Milić-Aškrabić, J.; Rajić, D. S.; Tasić, Lj; Djurić, S.; Kása, P.; Pintye-Hódi, K.

In: Drug Development and Industrial Pharmacy, Vol. 23, No. 11, 1997, p. 1123-1129.

Research output: Contribution to journalArticle

Milić-Aškrabić, J, Rajić, DS, Tasić, L, Djurić, S, Kása, P & Pintye-Hódi, K 1997, 'Etodolac and solid dispersion with β-cyclodextrin', Drug Development and Industrial Pharmacy, vol. 23, no. 11, pp. 1123-1129.
Milić-Aškrabić J, Rajić DS, Tasić L, Djurić S, Kása P, Pintye-Hódi K. Etodolac and solid dispersion with β-cyclodextrin. Drug Development and Industrial Pharmacy. 1997;23(11):1123-1129.
Milić-Aškrabić, J. ; Rajić, D. S. ; Tasić, Lj ; Djurić, S. ; Kása, P. ; Pintye-Hódi, K. / Etodolac and solid dispersion with β-cyclodextrin. In: Drug Development and Industrial Pharmacy. 1997 ; Vol. 23, No. 11. pp. 1123-1129.
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