Etiopathogenesis of otosclerosis

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The objectives of our study was to review our current knowledge of the etiopathogenesis of otosclerotic bone remodeling including genetics, viral infection, autoimmunity and inflammation and to discuss disease pathogenesis with relevance to pharmacotherapy. Relevant publications on the etiopathogenesis, molecular biology, genetics and histopathology of otosclerosis from 1984 to 2009 were analyzed. Otosclerosis is a bone remodeling disorder of the human otic capsule; however, the etiopathogenesis remains unclear. Genetic predisposition, disturbed bone metabolism, persistent measles virus infection, autoimmunity, and hormonal and environmental factors also may play contributing roles in the pathogenesis of otosclerosis. Since diagnosis of otosclerosis is still based on histopathological examination of the removed stapes footplate, systemic prospective studies based on comprehensive histopathological and molecular biological analysis are necessary to obtain further information on the background of the disease.

Original languageEnglish
Pages (from-to)1337-1349
Number of pages13
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume267
Issue number9
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Otosclerosis
Bone Remodeling
Virus Diseases
Autoimmunity
Molecular Biology
Stapes
Measles virus
Genetic Predisposition to Disease
Capsules
Ear
Publications
Prospective Studies
Inflammation
Bone and Bones
Drug Therapy

Keywords

  • Autoimmunity
  • Etiopathogenesis
  • Genetics
  • Inflammation
  • Measles virus and epidemiology
  • Otosclerosis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Etiopathogenesis of otosclerosis. / Karosi, T.; Sziklai, I.

In: European Archives of Oto-Rhino-Laryngology, Vol. 267, No. 9, 09.2010, p. 1337-1349.

Research output: Contribution to journalArticle

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