ZUR BEDEUTUNG DER ZYTOTOXISCHEN AKTIVITAT DER MUTTERLICHEN LYMPHOZYTEN FUR DIE ATIOLOGIE DER INTRAUTERINEN MANGELENTWICKLUNG

Translated title of the contribution: Etiological aspects of increased maternal lymphocyte cytotoxicity in intrauterine growth retardation

P. Varga, A. Scharl, J. Szekeres-Barthó, A. Bolte, Z. Szereday

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Natural lymphocyte cytotoxicity of 99 pregnant women delivering intrauterine growth retarded (IUGR) babies was compared to that of 460 women with normal pregnancies. Lymphocytes separated from maternal blood were used as effectors in the in vitro cytotoxicity test using human embryonic fibroblast cells as target. The cytotoxicity test was based on the assessment of endogeneous alkaline phosphatase activity of the target cells. A definite shift towards IUGR pregnancies was observed in the distribution of patients when analyzed according to step by step increase of lymphocyte cytotoxicity values. The incidence of increased cytotoxic activity (≥ 40%) was three times higher in the group of women with IUGR pregnancies than that in the control group. Within the group of women showing increased immunoreactivity during pregnancy the participation of IUGR pregnancies was 40.4%, while only 9.7% of the women with normal cytotoxicity belonged to the IUGR group. Combined analysis of ponderal indices and cytotoxicity values suggests that increased immunoreactivity is associated with a nutritive insufficiency resulting in the dysproportionate form of IUGR.

Original languageGerman
Pages (from-to)167-171
Number of pages5
JournalZeitschrift fur Geburtshilfe und Perinatologie
Volume193
Issue number4
Publication statusPublished - 1989

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Fetal Growth Retardation
Mothers
Lymphocytes
Pregnancy
Growth
Alkaline Phosphatase
Pregnant Women
Fibroblasts
Weights and Measures
Control Groups
Incidence

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

ZUR BEDEUTUNG DER ZYTOTOXISCHEN AKTIVITAT DER MUTTERLICHEN LYMPHOZYTEN FUR DIE ATIOLOGIE DER INTRAUTERINEN MANGELENTWICKLUNG. / Varga, P.; Scharl, A.; Szekeres-Barthó, J.; Bolte, A.; Szereday, Z.

In: Zeitschrift fur Geburtshilfe und Perinatologie, Vol. 193, No. 4, 1989, p. 167-171.

Research output: Contribution to journalArticle

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