Ethylcholine mustard aziridinium blocks the axoplasmic transport of acetylcholinesterase in cholinergic nerve fibres of the rat

P. Kása, I. Hanin

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Abstract

A cholinotoxin, ethylcholine mustard aziridinium ion, (AF64A) specifically and ireversibly blocks the intraaxonal transport of acetylcholinesterase in the rat. Impairment of the transport of this enzyme in the septo-hippocampal cholinergic fibres and in the sciatic nerve has been studied, using different doses of AF64A. It is demonstrated that the effect on the axonal transport is dose-dependent, but is not related to the mode of drug application. AF64A thus may exert its neurotoxic effects on cholinergic neurons at several target sites of action. In addition to the localized presynaptic mechanisms, it may also be compromising cholinergic function by inhibiting axonal transport in vivo.

Original languageEnglish
Pages (from-to)343-345
Number of pages3
JournalHistochemistry
Volume83
Issue number4
DOIs
Publication statusPublished - Jul 1985

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Cholinergic Fibers
Axonal Transport
Acetylcholinesterase
Nerve Fibers
Cholinergic Neurons
Sciatic Nerve
Cholinergic Agents
Ions
ethylcholine aziridinium
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Anatomy

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Ethylcholine mustard aziridinium blocks the axoplasmic transport of acetylcholinesterase in cholinergic nerve fibres of the rat. / Kása, P.; Hanin, I.

In: Histochemistry, Vol. 83, No. 4, 07.1985, p. 343-345.

Research output: Contribution to journalArticle

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