Ethanol inhibition of stress-related tachycardia involves medullary NMDA receptors

Károly Varga, Gábor Lovas, Miklós Palkovits, George Kunos

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In rats, neurons in the perifornical area of the hypothalamus send descending projections to the commissural part of the nucleus tractus solitarii as demonstrated by an anterograde tracer study. In urethane-anaesthetised rats, stimulation of neurons in the perifornical area by microinjection of bicuculline or 6-OH-saclofen causes tachycardia and inhibits baroreflex bradycardia. The effects elicited from the perifornical area are similar in magnitude to those elicited from the adjacent dorsomedial nucleus, also called the hypothalamic defense area. Microinjection into the nucleus tractus solitarii of the NMDA (N-methyl-D-aspartate) receptor antagonist, AP-7 (2-amino-7-phosphonoheptanoic acid), inhibits the tachycardic response to stimulation of the perifornical area. Injection of ethanol intravenously or into the nucleus tractus solitarii also inhibits this tachycardic response, but causes no further inhibition when combined with AP-7. We conclude that the perifornical area is part of the hypothalamic defense area, and it is under strong, tonic GABAergic inhibition mediated by both GABA, and GABA, receptors. Furthermore, descending input from the perifornical area to the nucleus tractus solitarii is via an NMDA synapse, and ethanol inhibits stress-related tachycardia by inhibiting these NMDA receptors in the nucleus tractus solitarii.

Original languageEnglish
Pages (from-to)145-153
Number of pages9
JournalEuropean Journal of Pharmacology
Volume310
Issue number2-3
DOIs
Publication statusPublished - Aug 29 1996

Keywords

  • Defense area
  • GABA (γ-aminobutyric acid)
  • Glutamate
  • Nucleus tractus solitarii
  • Perifornical area

ASJC Scopus subject areas

  • Pharmacology

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