Ethanol-induced signal transducing mechanism associated with a transient antiviral state in human amniotic cells

A. Markovits, G. Premecz, I. Lorincz, G. Bagi, J. Nagy, T. Farkas, I. Foldes

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Short-term effects of ethanol on human amnion cells were investigated by studying the cellular signaling processes and the replication of vesicular stomatitis virus. Treatment of human amniotic cells with ethanol transiently triggers the breakdown of inositol phospholipids, stimulates intracellular [Ca2+](i) mobilization and activates the translocation of protein kinase C. Activation of this signal transduction mechanism is associated with the development of an antiviral state, as proven by studying 3H-uridine incorporation into the RNA of vesicular stomatitis virus. Induction of the antiviral state in human amniotic cells correlates with the solubility of the alcohols in the lipid membrane of the cells.

Original languageEnglish
Pages (from-to)495-502
Number of pages8
JournalJournal of Studies on Alcohol
Issue number4
Publication statusPublished - Jan 1 1994


ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychology(all)

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