Etamsylate as inhibitor of prostaglandin biosynthesis in pregnant human myometrium in vitro

L. Kovács, G. Falkay

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Abstract

The effects of etamsylate on prostaglandin (PG) biosynthesis in microsomes of pregnant human myometrium in vitro have been determined, and compared with those of indomethacin. Both drugs inhibited PG biosynthesis, indomethacin being the more potent inhibitor of the two. Etamsylate inhibited synthesis of 6-oxo-PGF, PGF, PGE2, and thromboxane B2; increasing the concentration of etamsylate increased the inhibition of synthesis. It is suggested that etamsylate has no anti-cyclo-oxygenase activity, but acts by inhibiting the activity of prostacyclin synthetase, endoperoxide reductase, endoperoxide isomerase, and thromboxane synthetase.

Original languageEnglish
Pages (from-to)1182-1183
Number of pages2
JournalExperientia
Volume37
Issue number11
DOIs
Publication statusPublished - Nov 1 1981

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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