Estrogen signalling in the pathogenesis of age-related macular degeneration

Kai Kaarniranta, Anna Machalińska, Zoltán Veréb, Antero Salminen, Goran Petrovski, Anu Kauppinen

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Age-related macular degeneration (AMD) is a multifactorial eye disease that is associated with aging, family history, smoking, obesity, cataract surgery, arteriosclerosis, hypertension, hypercholesterolemia and unhealthy diet. Gender has commonly been classified as a weak or inconsistent risk factor for AMD. This disease is characterized by degeneration of retinal pigment epithelial (RPE) cells, Bruch's membrane, and choriocapillaris, which secondarily lead to damage and death of photoreceptor cells and central visual loss. Pathogenesis of AMD involves constant oxidative stress, chronic inflammation, and increased accumulation of lipofuscin and drusen. Estrogen has both anti-oxidative and anti-inflammatory capacity and it regulates signaling pathways that are involved in the pathogenesis of AMD. In this review, we discuss potential cellular signaling targets of estrogen in retinal cells and AMD pathology.

Original languageEnglish
Pages (from-to)226-233
Number of pages8
JournalCurrent Eye Research
Volume40
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Degeneration
  • Estrogen
  • Inflammation
  • Macula
  • Oxidative stress
  • Retina

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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  • Cite this

    Kaarniranta, K., Machalińska, A., Veréb, Z., Salminen, A., Petrovski, G., & Kauppinen, A. (2015). Estrogen signalling in the pathogenesis of age-related macular degeneration. Current Eye Research, 40(2), 226-233. https://doi.org/10.3109/02713683.2014.925933