Estrogen replacement reverses the effect of ovariectomy on small artery biomechanics

N. Ács, B. Székécs, G. Nádasy, Á László, S. Várbíró, R. Kakucs, Z. Miklós, M. Szentiványi, E. Monos

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to determine the effects of estrogen deficiency and hormone replacement on the biomechanical properties of rat saphenous artery. Adult virgin Sprague-Dawley rats were pharmacologically ovariectomised by 750 μg/kg triptorelin im. every 4th week and received either 450 μg/kg estradiol propionate (10 animals) or its vehicle (10 animals) im. every week. Ten other animals were not ovariectomised, only the vehicle was administered for the same periods of time (control group). After 12 weeks of treatment, cylindrical segments of the saphenous artery were isolated and cannulated at both ends. Pressure-diameter curves in the range of 0-200 mmHg were recorded from segments in normal KR, with norepinephrine (1.58×10-5M), and then with papaverine (2.84×10-5M). Pharmacological ovariectomy decreased, estrogen replacement increased significantly the passive diameter of the arteries (internal radius at 100 mmHg IP:340±3μm vs. 300±9μm in the estrogen treated and untreated group, respectively, p

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number3
Publication statusPublished - 1997

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Estrogen Replacement Therapy
ovariectomy
Biomechanics
Ovariectomy
Biomechanical Phenomena
arteries
estrogens
Estrogens
Animals
Arteries
Rats
Triptorelin Pamoate
papaverine
animals
Papaverine
rats
Propionates
norepinephrine
propionates
Sprague Dawley Rats

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Estrogen replacement reverses the effect of ovariectomy on small artery biomechanics. / Ács, N.; Székécs, B.; Nádasy, G.; László, Á; Várbíró, S.; Kakucs, R.; Miklós, Z.; Szentiványi, M.; Monos, E.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Ács, N, Székécs, B, Nádasy, G, László, Á, Várbíró, S, Kakucs, R, Miklós, Z, Szentiványi, M & Monos, E 1997, 'Estrogen replacement reverses the effect of ovariectomy on small artery biomechanics', FASEB Journal, vol. 11, no. 3.
Ács, N. ; Székécs, B. ; Nádasy, G. ; László, Á ; Várbíró, S. ; Kakucs, R. ; Miklós, Z. ; Szentiványi, M. ; Monos, E. / Estrogen replacement reverses the effect of ovariectomy on small artery biomechanics. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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AU - Nádasy, G.

AU - László, Á

AU - Várbíró, S.

AU - Kakucs, R.

AU - Miklós, Z.

AU - Szentiványi, M.

AU - Monos, E.

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