Estrogen receptor immunoreactivity is present in the majority of central histaminergic neurons

Evidence for a new neuroendocrine pathway associated with luteinizing hormone-releasing hormone-synthesizing neurons in rats and humans

Cs Fekete, P. H. Strutton, F. R A Cagampang, E. Hrabovszky, I. Kalló, P. J. Shughrue, E. Dobó, E. Mihály, L. Baranyi, H. Okada, P. Panula, I. Merchenthaler, C. W. Coen, Zsolt Liposits

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The central regulation of the preovulatory LH surge requires a complex sequence of interactions between neuronal systems that impinge on LH-releasing hormone (LHRH)-synthesizing neurons. The reported absence of estrogen receptors (ERs) in LHRH neurons indicates that estrogen-receptive neurons that are afferent to LHRH neurons are involved in mediating the effects of this steroid. We now present evidence indicating that central histaminergic neurons, exclusively located in the tuberomammillary complex of the caudal diencephalon, serve as an important relay in this system. Evaluation of this system revealed that 76% of histamine-synthesising neurons display ERα-immunoreactivity in their nucleus; furthermore histaminergic axons exhibit axo-dendritic and axo-somatic appositions onto LHRH neurons in both the rodent and the human brain. Our in vivo studies show that the intracerebroventricular administration of the histamine-1 (H1) receptor antagonist, mepyramine, but not the H2 receptor antagonist, ranitidine, can block the LH surge in ovariectomized estrogen-treated rats. These data are consistent with the hypothesis that the positive feedback effect of estrogen in the induction of the LH surge involves estrogen-receptive histamine-containing neurons in the tuberomammillary nucleus that relay the steroid signal to LHRH neurons via H1 receptors.

Original languageEnglish
Pages (from-to)4335-4341
Number of pages7
JournalEndocrinology
Volume140
Issue number9
Publication statusPublished - 1999

Fingerprint

Gonadotropin-Releasing Hormone
Estrogen Receptors
Neurons
Estrogens
Histamine Receptors
Histamine
Steroids
Lateral Hypothalamic Area
Pyrilamine
Afferent Neurons
Diencephalon
Histamine H2 Receptors
Ranitidine
Axons
Rodentia
Brain

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Estrogen receptor immunoreactivity is present in the majority of central histaminergic neurons : Evidence for a new neuroendocrine pathway associated with luteinizing hormone-releasing hormone-synthesizing neurons in rats and humans. / Fekete, Cs; Strutton, P. H.; Cagampang, F. R A; Hrabovszky, E.; Kalló, I.; Shughrue, P. J.; Dobó, E.; Mihály, E.; Baranyi, L.; Okada, H.; Panula, P.; Merchenthaler, I.; Coen, C. W.; Liposits, Zsolt.

In: Endocrinology, Vol. 140, No. 9, 1999, p. 4335-4341.

Research output: Contribution to journalArticle

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abstract = "The central regulation of the preovulatory LH surge requires a complex sequence of interactions between neuronal systems that impinge on LH-releasing hormone (LHRH)-synthesizing neurons. The reported absence of estrogen receptors (ERs) in LHRH neurons indicates that estrogen-receptive neurons that are afferent to LHRH neurons are involved in mediating the effects of this steroid. We now present evidence indicating that central histaminergic neurons, exclusively located in the tuberomammillary complex of the caudal diencephalon, serve as an important relay in this system. Evaluation of this system revealed that 76{\%} of histamine-synthesising neurons display ERα-immunoreactivity in their nucleus; furthermore histaminergic axons exhibit axo-dendritic and axo-somatic appositions onto LHRH neurons in both the rodent and the human brain. Our in vivo studies show that the intracerebroventricular administration of the histamine-1 (H1) receptor antagonist, mepyramine, but not the H2 receptor antagonist, ranitidine, can block the LH surge in ovariectomized estrogen-treated rats. These data are consistent with the hypothesis that the positive feedback effect of estrogen in the induction of the LH surge involves estrogen-receptive histamine-containing neurons in the tuberomammillary nucleus that relay the steroid signal to LHRH neurons via H1 receptors.",
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AU - Strutton, P. H.

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