Estrogen effects on tyrosine hydroxylase-immunoreactive cells in the ventral mesencephalon of the female rat: Further evidence for the two cell hypothesis of dopamine function

Attila Zsarnovszky, Trudy J. Scalise, Tamas L. Horvath, Frederick Naftolin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The present study was undertaken to examine the differential effect of estrogen (E) on the expression of tyrosine hydroxylase (TH) in the substantia nigra compacta (SNc) and in two subdivisions of the ventral tegmental area in ovariectomized (ovx) and ovx plus estradiol benzoate (ovx+E)-treated female rats. Cell counting of TH-immunoreactive perikarya of the SNc, paranigral (PN) and interfascicular (IF) nucleus was performed and compared. Our findings demonstrate that E eliminated TH immunoreactivity from a number of midbrain neurons, while it seemingly did not affect it in others. This signifies a differential effect of E on ventral mesencephalic dopaminergic neurons.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalBrain research
Volume868
Issue number2
DOIs
Publication statusPublished - Jun 23 2000

Keywords

  • Estrogen
  • Female rat
  • Tyrosine hydroxylase
  • Ventral mesencephalon

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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