Estrogen effects on arcuate neurons in rat. An in situ electrophysiological study

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Abstract

IN acute experiments, the effects of i.p. 17β-estradiol on the activity of arcuate neurons were studied in ovariectomized rats. 17β-Estradiol (100 μg(100g, i.p.) increased the spontaneous activity of the observed arcuate neurons with a latency of 20-25min. In some neurons spontaneous activity could be influenced by stimulation of the olfactory and somatosensory systems. Activation of the trigeminal system significantly increased the spontaneous activity of the studied units, while stimulation of the accessory olfactory bulb decreased it, both with and without 17β-estradiol treatment. It is suggested that the 20.25 min latency of the 17β-estradiol effect is based not so much on membrane as on genomic mechanisms. This suggestion is supported by immunocytochemical studies: 17β-estradiol treatment significantly decreased the number of GABA-positive axo-somatic synapses in the arcuate nucleus.

Original languageEnglish
Pages (from-to)3649-3652
Number of pages4
JournalNeuroreport
Volume10
Issue number17
DOIs
Publication statusPublished - Nov 26 1999

Keywords

  • 17β-Estradiol
  • Arcuate nucleus
  • GABA
  • Neuronal activity
  • Neuronal plasticity
  • Steroids

ASJC Scopus subject areas

  • Neuroscience(all)

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