Estimation of the single stranded region in the nuclear DNA of mouse tissues during aging with special reference to the brain

Nozomu Mori, S. Goto

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The proportion of single stranded DNA in various tissues of mouse during aging was examined by measuring sensitivity to a single-strand specific nuclease. Brain DNA from mice of more than 15 mth old contained 3% of the single stranded regions while that from younger animals contained 2%. The DNAs from liver, kidney, heart and spleen did not show significant age-associated changes.

Original languageEnglish
Pages (from-to)143-150
Number of pages8
JournalArchives of Gerontology and Geriatrics
Volume1
Issue number2
DOIs
Publication statusPublished - 1982

Fingerprint

brain
animal
Single-Stranded DNA
DNA
Brain
Spleen
Kidney
Liver

Keywords

  • aging
  • brain
  • nuclease S1
  • single stranded DNA

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Cite this

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abstract = "The proportion of single stranded DNA in various tissues of mouse during aging was examined by measuring sensitivity to a single-strand specific nuclease. Brain DNA from mice of more than 15 mth old contained 3{\%} of the single stranded regions while that from younger animals contained 2{\%}. The DNAs from liver, kidney, heart and spleen did not show significant age-associated changes.",
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AB - The proportion of single stranded DNA in various tissues of mouse during aging was examined by measuring sensitivity to a single-strand specific nuclease. Brain DNA from mice of more than 15 mth old contained 3% of the single stranded regions while that from younger animals contained 2%. The DNAs from liver, kidney, heart and spleen did not show significant age-associated changes.

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