Estimation of impurity profiles of drugs and related materials, Part 13: identification of impurities in estradiol

Sandor Gorog, Janos Brlik, Attila Csehi, Zsuzsanna Halmos, Bulcsu Herenyi, Peter Horvath, Ferenc Dravecz, Dezso Bor

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Three minor impurities were detected and identified in estradiol bulk material. Estradiol-17-acetate was identified by HPLC and TLC retention matching with an authentic sample. 9(11)-Dehydroestradiol was identified by means of HPLC/diode-array UV spectroscopy. On the basis of its mass spectrum and HPLC/diode-array UV spectrum the third impurity was the 4-chloro derivative of estradiol. The identification of the impurities was confirmed by synthesizing the proposed structures and retention matching of the impurities and the synthesized materials.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalAnalytical methods & instrumentation
Volume2
Issue number3
Publication statusPublished - Jan 1 1995

ASJC Scopus subject areas

  • Engineering(all)

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