Estimation of impurity profiles in drugs and related materials. Part 11 - the role of chromatographic and spectroscopic methods in the estimation of side-reactions in drug syntheses

S. Görög, G. Balogh, A. Csehi, É Csizér, M. Gazdag, Zs Halmos, B. Hegedüs, B. Herényi, P. Horváth, A. Laukó

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Impurities in drugs are classified on the basis of the types of side-reactions in drug syntheses resulting in their formation. This is shown by summarizing the authors' earlier results in the field of impurity profiling of 19-nor-steroids, ethynodiol diacetate, mazipredone, pipecuronium bromide, flumecinol, enalapril, pyridinol carbamate, phenylbutazone, thymotrinan and some new results related to danazol and famotidine.

Original languageEnglish
Pages (from-to)1219-1226
Number of pages8
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume11
Issue number11-12
DOIs
Publication statusPublished - 1993

Keywords

  • 19-nor-steroids
  • Impurity profiling
  • danazol
  • estimation of side-reactions
  • famotidine
  • flumecinol
  • pipecuronium bromide.

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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