Ester composition of carnitine in the perfusate of liver and in the plasma of donor rats

Attila SANDOR, Gyula KISPAL, Bela MELEGH, Istvan ALKONYI

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Abstract

When the carnitine pool of fed rats was labelled with tritium, in non‐recirculating perfusate of their liver 44% of acid‐soluble 3H activity was identified as free carnitine and 47% as short‐chain acylcarnitine. Of the latter component acetylcarnitine accounted for 30% and propionylcarnitine for 10% of total acid‐soluble. In plasma the contribution of short‐chain acylcarnitines to total carnitine in fed, fasted and diabetic rats was 15.6%, 43.1% and 48.0%, respectively. Recirculating perfusion of livers from the same animals revealed that livers from fed rats released short‐chain acylcarnitines as much as 56.2% of total and this proportion did not increase further in the other two groups. At the same time, ketone bodies in the perfusate increased gradually in the fed, fasted and diabetic group, paralleling the plasma ketone levels. Although liver supplies the organism with carnitine the increment of plasma short‐chain acylcarnitines seen in ketosis is not a result of some extra output by the liver.

Original languageEnglish
Pages (from-to)443-445
Number of pages3
JournalEuropean Journal of Biochemistry
Volume170
Issue number1-2
DOIs
Publication statusPublished - Dec 1987

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ASJC Scopus subject areas

  • Biochemistry

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