Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD)

Zsuzsanna Táncos, Eszter Varga, Eszter Kovács, A. Dinnyés, Julianna Kobolák

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Peripheral blood mononuclear cells (PBMCs) were collected from a clinically characterised 84-year old male with late onset Alzheimer's disease (LOAD). The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus delivery system. The transgene-free iPSC showed pluripotency verified by immunocytochemistry for pluripotency markers and differentiated spontaneously towards the 3 germ layers in vitro. Furthermore, the iPSC line showed normal karyotype. Our model might offer a good platform to further study the pathomechanism of sporadic AD, to identify early biomarkers and also for drug testing and gene therapy studies.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalStem Cell Research
Volume17
Issue number1
DOIs
Publication statusPublished - Jul 1 2016

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ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Medicine(all)

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