Establishment and functioning of intrathymic microenvironments

Graham Anderson, William E. Jenkinson, Terry Jones, Sonia M. Parnell, Francesca A M Kinsella, Andrea J. White, J. Pongrácz, Simona W. Rossi, Eric J. Jenkinson

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

Original languageEnglish
Pages (from-to)10-27
Number of pages18
JournalImmunological Reviews
Volume209
DOIs
Publication statusPublished - Feb 2006

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T-Lymphoid Precursor Cells
Thymus Gland
Stromal Cells
Immune System
Maintenance
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Anderson, G., Jenkinson, W. E., Jones, T., Parnell, S. M., Kinsella, F. A. M., White, A. J., ... Jenkinson, E. J. (2006). Establishment and functioning of intrathymic microenvironments. Immunological Reviews, 209, 10-27. https://doi.org/10.1111/j.0105-2896.2006.00347.x

Establishment and functioning of intrathymic microenvironments. / Anderson, Graham; Jenkinson, William E.; Jones, Terry; Parnell, Sonia M.; Kinsella, Francesca A M; White, Andrea J.; Pongrácz, J.; Rossi, Simona W.; Jenkinson, Eric J.

In: Immunological Reviews, Vol. 209, 02.2006, p. 10-27.

Research output: Contribution to journalArticle

Anderson, G, Jenkinson, WE, Jones, T, Parnell, SM, Kinsella, FAM, White, AJ, Pongrácz, J, Rossi, SW & Jenkinson, EJ 2006, 'Establishment and functioning of intrathymic microenvironments', Immunological Reviews, vol. 209, pp. 10-27. https://doi.org/10.1111/j.0105-2896.2006.00347.x
Anderson G, Jenkinson WE, Jones T, Parnell SM, Kinsella FAM, White AJ et al. Establishment and functioning of intrathymic microenvironments. Immunological Reviews. 2006 Feb;209:10-27. https://doi.org/10.1111/j.0105-2896.2006.00347.x
Anderson, Graham ; Jenkinson, William E. ; Jones, Terry ; Parnell, Sonia M. ; Kinsella, Francesca A M ; White, Andrea J. ; Pongrácz, J. ; Rossi, Simona W. ; Jenkinson, Eric J. / Establishment and functioning of intrathymic microenvironments. In: Immunological Reviews. 2006 ; Vol. 209. pp. 10-27.
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