Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes

Experience of the PedPump Study in 17 countries

T. Danne, T. Battelino, P. Jarosz-Chobot, O. Kordonouri, E. Pánkowska, J. Ludvigsson, E. Schober, E. Kaprio, T. Saukkonen, M. Nicolino, N. Tubiana-Rufi, C. Klinkert, H. Haberland, A. Vazeou, L. Madacsy, D. Zangen, V. Cherubini, I. Rabbone, S. Toni, C. De Beaufort & 14 others W. Bakker-van Waarde, N. Van Den Berg, I. Volkov, R. Barrio, R. Hanas, U. Zumsteg, B. Kuhlmann, C. Aebi, U. Schumacher, S. Gschwend, P. Hindmarsh, M. Torres, N. Shehadeh, M. Phillip

Research output: Contribution to journalArticle

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Abstract

Aims/hypothesis: To assess the use of paediatric continuous subcutaneous infusion (CSII) under real-life conditions by analysing data recorded for up to 90 days and relating them to outcome. Methods: Pump programming data from patients aged 0-18 years treated with CSII in 30 centres from 16 European countries and Israel were recorded during routine clinical visits. HbA 1c was measured centrally. Results: A total of 1,041 patients (age: 11.8±4.2 years; diabetes duration: 6.0±3.6 years; average CSII duration: 2.0±1.3 years; HbA1c: 8.0±1.3% [means±SD]) participated. Glycaemic control was better in preschool (n=142; 7.5±0.9%) and pre-adolescent (6-11 years, n=321; 7.7±1.0%) children than in adolescent patients (12-18 years, n=578; 8.3±1.4%). There was a significant negative correlation between HbA1c and daily bolus number, but not between HbA1c and total daily insulin dose. The use of 1c level >7.5%. The incidence of severe hypoglycaemia and ketoacidosis was 6.63 and 6.26 events per 100 patient-years, respectively. Conclusions/ interpretation: This large paediatric survey of CSII shows that glycaemic targets can be frequently achieved, particularly in young children, and the incidence of acute complications is low. Adequate substitution of basal and prandial insulin is associated with a better HbA1c.

Original languageEnglish
Pages (from-to)1594-1601
Number of pages8
JournalDiabetologia
Volume51
Issue number9
DOIs
Publication statusPublished - Sep 2008

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Subcutaneous Infusions
Type 1 Diabetes Mellitus
Insulin
Pediatrics
Ketosis
Incidence
Israel
Hypoglycemia
Meals

Keywords

  • Adolescents
  • Children
  • Diabetic
  • HbA
  • Hypoglycaemia
  • Insulin infusion systems
  • Ketoacidosis
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes : Experience of the PedPump Study in 17 countries. / Danne, T.; Battelino, T.; Jarosz-Chobot, P.; Kordonouri, O.; Pánkowska, E.; Ludvigsson, J.; Schober, E.; Kaprio, E.; Saukkonen, T.; Nicolino, M.; Tubiana-Rufi, N.; Klinkert, C.; Haberland, H.; Vazeou, A.; Madacsy, L.; Zangen, D.; Cherubini, V.; Rabbone, I.; Toni, S.; De Beaufort, C.; Bakker-van Waarde, W.; Van Den Berg, N.; Volkov, I.; Barrio, R.; Hanas, R.; Zumsteg, U.; Kuhlmann, B.; Aebi, C.; Schumacher, U.; Gschwend, S.; Hindmarsh, P.; Torres, M.; Shehadeh, N.; Phillip, M.

In: Diabetologia, Vol. 51, No. 9, 09.2008, p. 1594-1601.

Research output: Contribution to journalArticle

Danne, T, Battelino, T, Jarosz-Chobot, P, Kordonouri, O, Pánkowska, E, Ludvigsson, J, Schober, E, Kaprio, E, Saukkonen, T, Nicolino, M, Tubiana-Rufi, N, Klinkert, C, Haberland, H, Vazeou, A, Madacsy, L, Zangen, D, Cherubini, V, Rabbone, I, Toni, S, De Beaufort, C, Bakker-van Waarde, W, Van Den Berg, N, Volkov, I, Barrio, R, Hanas, R, Zumsteg, U, Kuhlmann, B, Aebi, C, Schumacher, U, Gschwend, S, Hindmarsh, P, Torres, M, Shehadeh, N & Phillip, M 2008, 'Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes: Experience of the PedPump Study in 17 countries', Diabetologia, vol. 51, no. 9, pp. 1594-1601. https://doi.org/10.1007/s00125-008-1072-2
Danne, T. ; Battelino, T. ; Jarosz-Chobot, P. ; Kordonouri, O. ; Pánkowska, E. ; Ludvigsson, J. ; Schober, E. ; Kaprio, E. ; Saukkonen, T. ; Nicolino, M. ; Tubiana-Rufi, N. ; Klinkert, C. ; Haberland, H. ; Vazeou, A. ; Madacsy, L. ; Zangen, D. ; Cherubini, V. ; Rabbone, I. ; Toni, S. ; De Beaufort, C. ; Bakker-van Waarde, W. ; Van Den Berg, N. ; Volkov, I. ; Barrio, R. ; Hanas, R. ; Zumsteg, U. ; Kuhlmann, B. ; Aebi, C. ; Schumacher, U. ; Gschwend, S. ; Hindmarsh, P. ; Torres, M. ; Shehadeh, N. ; Phillip, M. / Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes : Experience of the PedPump Study in 17 countries. In: Diabetologia. 2008 ; Vol. 51, No. 9. pp. 1594-1601.
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abstract = "Aims/hypothesis: To assess the use of paediatric continuous subcutaneous infusion (CSII) under real-life conditions by analysing data recorded for up to 90 days and relating them to outcome. Methods: Pump programming data from patients aged 0-18 years treated with CSII in 30 centres from 16 European countries and Israel were recorded during routine clinical visits. HbA 1c was measured centrally. Results: A total of 1,041 patients (age: 11.8±4.2 years; diabetes duration: 6.0±3.6 years; average CSII duration: 2.0±1.3 years; HbA1c: 8.0±1.3{\%} [means±SD]) participated. Glycaemic control was better in preschool (n=142; 7.5±0.9{\%}) and pre-adolescent (6-11 years, n=321; 7.7±1.0{\%}) children than in adolescent patients (12-18 years, n=578; 8.3±1.4{\%}). There was a significant negative correlation between HbA1c and daily bolus number, but not between HbA1c and total daily insulin dose. The use of 1c level >7.5{\%}. The incidence of severe hypoglycaemia and ketoacidosis was 6.63 and 6.26 events per 100 patient-years, respectively. Conclusions/ interpretation: This large paediatric survey of CSII shows that glycaemic targets can be frequently achieved, particularly in young children, and the incidence of acute complications is low. Adequate substitution of basal and prandial insulin is associated with a better HbA1c.",
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T1 - Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes

T2 - Experience of the PedPump Study in 17 countries

AU - Danne, T.

AU - Battelino, T.

AU - Jarosz-Chobot, P.

AU - Kordonouri, O.

AU - Pánkowska, E.

AU - Ludvigsson, J.

AU - Schober, E.

AU - Kaprio, E.

AU - Saukkonen, T.

AU - Nicolino, M.

AU - Tubiana-Rufi, N.

AU - Klinkert, C.

AU - Haberland, H.

AU - Vazeou, A.

AU - Madacsy, L.

AU - Zangen, D.

AU - Cherubini, V.

AU - Rabbone, I.

AU - Toni, S.

AU - De Beaufort, C.

AU - Bakker-van Waarde, W.

AU - Van Den Berg, N.

AU - Volkov, I.

AU - Barrio, R.

AU - Hanas, R.

AU - Zumsteg, U.

AU - Kuhlmann, B.

AU - Aebi, C.

AU - Schumacher, U.

AU - Gschwend, S.

AU - Hindmarsh, P.

AU - Torres, M.

AU - Shehadeh, N.

AU - Phillip, M.

PY - 2008/9

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N2 - Aims/hypothesis: To assess the use of paediatric continuous subcutaneous infusion (CSII) under real-life conditions by analysing data recorded for up to 90 days and relating them to outcome. Methods: Pump programming data from patients aged 0-18 years treated with CSII in 30 centres from 16 European countries and Israel were recorded during routine clinical visits. HbA 1c was measured centrally. Results: A total of 1,041 patients (age: 11.8±4.2 years; diabetes duration: 6.0±3.6 years; average CSII duration: 2.0±1.3 years; HbA1c: 8.0±1.3% [means±SD]) participated. Glycaemic control was better in preschool (n=142; 7.5±0.9%) and pre-adolescent (6-11 years, n=321; 7.7±1.0%) children than in adolescent patients (12-18 years, n=578; 8.3±1.4%). There was a significant negative correlation between HbA1c and daily bolus number, but not between HbA1c and total daily insulin dose. The use of 1c level >7.5%. The incidence of severe hypoglycaemia and ketoacidosis was 6.63 and 6.26 events per 100 patient-years, respectively. Conclusions/ interpretation: This large paediatric survey of CSII shows that glycaemic targets can be frequently achieved, particularly in young children, and the incidence of acute complications is low. Adequate substitution of basal and prandial insulin is associated with a better HbA1c.

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KW - Children

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KW - Ketoacidosis

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