Erythrocyte defense mechanisms against free oxygen radicals in haemodialysed uraemic children

S. Túri, I. Németh, Ilona Vargha, B. Matkovics, Éva Dobos

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Changes in erythrocyte lipid peroxidation (measured as the concentration of malonyl dialdehyde), glutathione metabolism, antioxidant enzyme activities (glutathione peroxidase, catalase, and superoxide dismutase), the oxidized products of haemoglobin (Hb), and hydrogen peroxide (H2O2)-induced haemolysis were studied in six children with chronic renal failure treated with serial acetate and bicarbonate haemodialysis (HD). Ten age- and sex-matched children acted as controls. Malonyl dialdehyde levels were significantly higher and antioxidant enzyme activities lower in uraemic red blood cells (RBCs) compared with controls (P2O2 haemolysis test revealed a mild (n=3) to increased (n=3) haemolysis in the uraemic RBCs. Oxidative haemolysis is probably a multifactorial process in uraemic patients, and may be an important risk factor in HD therapy.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalPediatric Nephrology
Volume5
Issue number2
DOIs
Publication statusPublished - Mar 1991

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Hemolysis
Free Radicals
Reactive Oxygen Species
Erythrocytes
Renal Dialysis
Antioxidants
Enzymes
Bicarbonates
Glutathione Peroxidase
Catalase
Hydrogen Peroxide
Lipid Peroxidation
Superoxide Dismutase
Chronic Kidney Failure
Glutathione
Hemoglobins
Acetates
Therapeutics

Keywords

  • Antioxidant enzymes
  • Chronic renal failure
  • Glutathione
  • Haemodialysis
  • Haemoglobin oxidation
  • Malonyl dialdehyde
  • Oxidative haemolysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Erythrocyte defense mechanisms against free oxygen radicals in haemodialysed uraemic children. / Túri, S.; Németh, I.; Vargha, Ilona; Matkovics, B.; Dobos, Éva.

In: Pediatric Nephrology, Vol. 5, No. 2, 03.1991, p. 179-183.

Research output: Contribution to journalArticle

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