Erythema marginatum as an early symptom of hereditary angioedema: Case report of 2 newborns

Inmaculada Martinez-Saguer, H. Farkas

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare genetic disease that causes recurrent swelling attacks that may affect various body tissues. Angioedematous attacks can be fatal in the case of upper airway edema and are often preceded by prodromal symptoms like erythema marginatum. Initial symptoms usually occur in the first decade of life. We report on manifestation of profound and recurrent erythema marginatum in 2 newborns. In both cases, prodromal symptoms could help determine the diagnosis of C1-INH-HAE such that, at a later time, angioedematous attacks could be treated promptly and effectively. Awareness of C1-INH-HAE is low among physicians and even lower among the general public. This report aims at raising the level of awareness and shows that initial symptoms of the potentially life-threatening condition can manifest in newborns and that erythema marginatum can even be present at birth. Recognition of early symptoms and timely diagnosis of the disease along with adequate education of the pediatrician and parents are a prerequisite for prompt and effective treatment of attacks and the successful management of the disease.

Original languageEnglish
Article numbere20152411
JournalPediatrics
Volume137
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Hereditary Angioedemas
Erythema
Prodromal Symptoms
Newborn Infant
Inborn Genetic Diseases
Disease Management
Rare Diseases
Edema
Parents
Parturition
Physicians
Education
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Erythema marginatum as an early symptom of hereditary angioedema : Case report of 2 newborns. / Martinez-Saguer, Inmaculada; Farkas, H.

In: Pediatrics, Vol. 137, No. 2, e20152411, 01.02.2016.

Research output: Contribution to journalArticle

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