Jendrassik ernö: Az epilepsia gyógyításá ról (orvosképzés 1911; 1:75-91). mit tudunk errol 100 ev utan?

Translated title of the contribution: Erno jendrassik: On the treatment of epilepsy (orvoskepzes 1911; 1:75-91). state of art after 100 years

Research output: Contribution to journalArticle

Abstract

Jendrassik, the famous internist was appointed in 1893 to professor of neurology. His publication on "Jendrassik-manoeuvre" was published in 1882. Under the influence of Charcot he was concerned with the research of hypnosis, hysteria and inherited neurological diseases. In the present publication he emphasized the importance of observation and differential diagnosis of epileptic fits. On the basis of his report a newly described form of Autosomal Dominant Nocturnal Frontal Lobe Epilepsy can be recognized. Jendrassik experienced that the bromide therapy reduced the frequency of grand-mal and Jackson-seizures but it proved to be ineffective in absence seizures. To avoid side effects he suggested taking bromide tablets instead of powder or tincture. Jendrassik proposed dietary restrictions and dermatological control to prevent "bromism". He thought that epilepsy may be a syndrome of occult brain disease developing in early childhood and doubted the inheritance. Recently genetic factors have been suspected in 40% of all epilepsies. The new era of treatment begun with the invention of Luminal. Nowadays we have approx. 50 antiepileptics; monotherapy is effective in many patients. The choice of antiepileptics depends on the type of the seizure. At the time of Jendrassik the bromide treatment had no more than 50% effectivity. By the use of modern drugs 65-70% of patients are seizure-free, without side effects. During the last 100 years the effectivity of medical treatment of epilepsy improved approximately by15-20%.

Original languageHungarian
Pages (from-to)49-54
Number of pages6
JournalOrvoskepzes
Volume86
Issue number1
Publication statusPublished - 2011

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Epilepsy
Bromides
Seizures
Anticonvulsants
Hysteria
Absence Epilepsy
Hypnosis
Brain Diseases
Therapeutics
Neurology
Powders
Tablets
Differential Diagnosis
Observation
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jendrassik ernö : Az epilepsia gyógyításá ról (orvosképzés 1911; 1:75-91). mit tudunk errol 100 ev utan? / Szirmai, I.

In: Orvoskepzes, Vol. 86, No. 1, 2011, p. 49-54.

Research output: Contribution to journalArticle

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