Eradication of Helicobacter pylori and improvement of hereditary angioneurotic oedema

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Abstract

Helicobacter pylori infection is thought to be a causal factor in various dermatological disorders. We assessed the frequency of H pylori infection in 65 patients with hereditary angioneurotic oedema. We measured the serum concentration of antibodies against H pylori and did the carbon-14-urease breath test in patients with positive H pylori serology. 19 of 65 patients had H pylori infection. All patients with infection, and 11 of 46 without infection, had a history of recurrent episodes of acute abdominal pain. We successfully eradicated H pylori infection in 18 patients. The frequency of abdominal symptoms was significantly higher in the infected group (p=0.002 after adjustment for age). In nine of 19 patients with dyspepsia, the frequency of oedematous episodes decreased from 100 over 10 months before eradication to 19 during the 10-month follow-up period. Screening for, and eradication of, H pylori infection seems to be justified in patients with hereditary angioneurotic oedema.

Original languageEnglish
Pages (from-to)1695-1696
Number of pages2
JournalThe Lancet
Volume358
Issue number9294
DOIs
Publication statusPublished - Nov 17 2001

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Hereditary Angioedemas
Helicobacter pylori
Pylorus
Infection
Breath Tests
Urease
Dyspepsia
Acute Pain
Helicobacter Infections
Serology
Abdominal Pain
Carbon
Antibodies
Serum

ASJC Scopus subject areas

  • Medicine(all)

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Eradication of Helicobacter pylori and improvement of hereditary angioneurotic oedema. / Farkas, H.; Füst, G.; Fekete, B.; Karádi, I.; Varga, L.

In: The Lancet, Vol. 358, No. 9294, 17.11.2001, p. 1695-1696.

Research output: Contribution to journalArticle

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