EQ-5D studies in musculoskeletal and connective tissue diseases in eight Central and Eastern European countries: a systematic literature review and meta-analysis

Zsombor Zrubka, Fanni Rencz, Jakub Závada, Dominik Golicki, Valentina Prevolnik Rupel, Judit Simon, Valentin Brodszky, Petra Baji, Guenka Petrova, Alexandru Rotar, L. Gulácsi, Márta Péntek

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Abstract

EQ-5D is becoming the preferred instrument to measure health-state utilities involved in health technology assessment. The objective of this study is to assess the state of EQ-5D research in musculoskeletal disorders in 8 Central and Eastern European countries and to provide a meta-analysis of EQ-5D index scores. Original research articles published in any language between Jan 2000 and Sept 2016 were included, if they reported any EQ-5D outcome from at least two musculoskeletal patients from Austria, Bulgaria, the Czech Republic, Hungary, Poland, Romania, Slovakia, or Slovenia. Risk of bias was assessed with the Cochrane Collaboration’s tool. Twenty-nine articles (5992 patients) were included on rheumatoid arthritis (n = 7), osteoporosis (n = 5), chronic pain (n = 5), osteoarthritis (n = 4), ankylosing spondylitis (n = 2), psoriatic arthritis (n = 2), total hip replacement (n = 2), and scleroderma (n = 2). Low back pain was under-represented, while studies in neck pain, systemic lupus erythematosus, gout, and childhood disorders were lacking. EQ-5D index scores were reported in 24 studies, while the version of the instrument and the value-set was not specified in 41% and 46% of the articles, respectively. Meta-analysis was performed on 24 disease states involving 6876 observation points. Intervention effect was reported in 22 subgroups, out of which risk of bias was low in 41%. This review provides recommendations to improve reporting standards of EQ-5D results and highlights potential areas for future research. Coordinated research in conditions with greatest public health impact as well as a development of a regional value-set could provide locally relevant health-state utilities that are transferable among countries within the region.

Original languageEnglish
Pages (from-to)1957-1977
Number of pages21
JournalRheumatology International
Volume37
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

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Keywords

  • Central and Eastern Europe
  • EQ-5D
  • Health-related quality of life
  • Meta-analysis
  • Musculoskeletal diseases
  • Patient reported outcomes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Zrubka, Z., Rencz, F., Závada, J., Golicki, D., Rupel, V. P., Simon, J., Brodszky, V., Baji, P., Petrova, G., Rotar, A., Gulácsi, L., & Péntek, M. (2017). EQ-5D studies in musculoskeletal and connective tissue diseases in eight Central and Eastern European countries: a systematic literature review and meta-analysis. Rheumatology International, 37(12), 1957-1977. https://doi.org/10.1007/s00296-017-3800-8