Epigenome-Wide Association Study of Tic Disorders

BIOS Consortium

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p <1.2 × 10-7). The strongest associated probe was cg15583738, located in an intergenic region on chromosome 8 (p = 1.98 × 10-6). Several of the top ranking probes (p <1 × 10-4) were in or nearby genes previously associated with neurological disorders (e.g., GABBRI, BLM, and ADAM10), warranting their further investigation in relation to tic disorders. The top significantly enriched gene ontology (GO) terms among higher ranking methylation sites included anatomical structure morphogenesis (GO:0009653, p = 4.6 × 10-15) developmental process (GO:0032502, p = 2.96 × 10-12), and cellular developmental process (GO:0048869, p = 1.96 × 10-12). Overall, these results provide a first insight into the epigenetic mechanisms of tic disorders. This first study assesses the role of DNA methylation in tic disorders, and it lays the foundations for future work aiming to unravel the biological mechanisms underlying the architecture of this disorder.

Original languageEnglish
Pages (from-to)699-709
Number of pages11
JournalTwin Research and Human Genetics
Volume18
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Tic Disorders
Gene Ontology
DNA Methylation
Netherlands
Developmental Genes
Methylation
Tics
Chromosomes, Human, Pair 8
Intergenic DNA
Nervous System Diseases
Morphogenesis
Epigenomics
Self Report
Psychiatry
Genome
Phenotype
Genes

Keywords

  • DNA methylation
  • epigenetics
  • EWAS
  • tics
  • Tourette syndrome

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Epigenome-Wide Association Study of Tic Disorders. / BIOS Consortium.

In: Twin Research and Human Genetics, Vol. 18, No. 6, 01.12.2015, p. 699-709.

Research output: Contribution to journalArticle

BIOS Consortium. / Epigenome-Wide Association Study of Tic Disorders. In: Twin Research and Human Genetics. 2015 ; Vol. 18, No. 6. pp. 699-709.
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