Epigenetic dysregulation of the host cell genome in Epstein-Barr virus-associated neoplasia

Hans Helmut Niller, Hans Wolf, Janos Minarovits

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV), a human herpesvirus, is associated with a wide variety of malignant tumors. The expression of the latent viral RNAs is under strict, host-cell dependent transcriptional control. This results in an almost complete transcriptional silencing of the EBV genome in memory B-cells. In tumor cells, germinal center B-cells and lymphoblastoid cells, distinct viral latency promoters are active. Epigenetic mechanisms contribute to this strict control. In EBV-infected cells, epigenetic mechanisms also alter the expression of cellular genes, including tumor suppressor genes. In Nasopharyngeal Carcinoma, the hypermethylation of certain cellular promoters is attributed to the upregulation of DNA methyltransferases by the viral oncoprotein LMP1 (latent membrane protein 1) via JNK/AP1-signaling. The role of other viral latency products in the epigenetic dysregulation of the cellular genome remains to be established. Analysis of epigenetic alterations in EBV-associated neoplasms may result in a better understanding of their pathogenesis and may facilitate the development of new therapies.

Original languageEnglish
Pages (from-to)158-164
Number of pages7
JournalSeminars in Cancer Biology
Volume19
Issue number3
DOIs
Publication statusPublished - Jun 1 2009

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Keywords

  • Epigenetic regulation
  • Epstein-Barr virus
  • Gastric carcinoma
  • Latency
  • Nasopharyngeal carcinoma
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Cancer Research

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