Epigenetic dysregulation of epstein-barr virus latency and development of autoimmune disease

Hans Helmut Niller, Hans Wolf, Eva Ay, J. Mináróvits

Research output: Chapter in Book/Report/Conference proceedingChapter

43 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is a human herpesvirus that persists in the memory B-cells of the majority of the world population in a latent form. Primary EBV infection is asymptomatic or causes a self-limiting disease, infectious mononucleosis. Virus latency is associated with a wide variety of neoplasms whereof some occur in immune suppressed individuals. Virus production does not occur in strict latency. The expression of latent viral oncoproteins and nontranslated RNAs is under epigenetic control via DNA methylation and histone modifications that results either in a complete silencing of the EBV genome in memory B cells, or in a cell-type dependent usage of a couple of latency promoters in tumor cells, germinal center B cells and lymphoblastoid cells (LCL, transformed by EBV in vitro). Both, latent and lytic EBV proteins elicit a strong immune response. In immune suppressed and infectious mononucleosis patients, an increased viral load can be detected in the blood. Enhanced lytic replication may result in new infection? and transformation-events and thus is a risk factor both for malignant transformation and the development of autoimmune diseases. An increased viral load or a changed presentation of a subset of lytic or latent EBV proteins that cross-react with cellular antigens may trigger pathogenic processes through molecular mimicry that result in multiple sclerosis (MS), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages82-102
Number of pages21
Volume711
DOIs
Publication statusPublished - 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume711
ISSN (Print)00652598

Fingerprint

Virus Latency
Human Herpesvirus 4
Viruses
Epigenomics
Autoimmune Diseases
Infectious Mononucleosis
B-Lymphocytes
Viral Load
Cells
Histone Code
Molecular Mimicry
Untranslated RNA
Epstein-Barr Virus Infections
Germinal Center
Herpesviridae
Oncogene Proteins
Viral RNA
DNA Methylation
Systemic Lupus Erythematosus
Carcinogens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Niller, H. H., Wolf, H., Ay, E., & Mináróvits, J. (2011). Epigenetic dysregulation of epstein-barr virus latency and development of autoimmune disease. In Advances in Experimental Medicine and Biology (Vol. 711, pp. 82-102). (Advances in Experimental Medicine and Biology; Vol. 711). https://doi.org/10.1007/978-1-4419-8216-2_7

Epigenetic dysregulation of epstein-barr virus latency and development of autoimmune disease. / Niller, Hans Helmut; Wolf, Hans; Ay, Eva; Mináróvits, J.

Advances in Experimental Medicine and Biology. Vol. 711 2011. p. 82-102 (Advances in Experimental Medicine and Biology; Vol. 711).

Research output: Chapter in Book/Report/Conference proceedingChapter

Niller, HH, Wolf, H, Ay, E & Mináróvits, J 2011, Epigenetic dysregulation of epstein-barr virus latency and development of autoimmune disease. in Advances in Experimental Medicine and Biology. vol. 711, Advances in Experimental Medicine and Biology, vol. 711, pp. 82-102. https://doi.org/10.1007/978-1-4419-8216-2_7
Niller HH, Wolf H, Ay E, Mináróvits J. Epigenetic dysregulation of epstein-barr virus latency and development of autoimmune disease. In Advances in Experimental Medicine and Biology. Vol. 711. 2011. p. 82-102. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-8216-2_7
Niller, Hans Helmut ; Wolf, Hans ; Ay, Eva ; Mináróvits, J. / Epigenetic dysregulation of epstein-barr virus latency and development of autoimmune disease. Advances in Experimental Medicine and Biology. Vol. 711 2011. pp. 82-102 (Advances in Experimental Medicine and Biology).
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