A leggyakoribb nem onkológiai eredetu nogyógyászati kórképek epigenetikai háttere

Translated title of the contribution: Epigenetic background of the most common non-oncologic gynecological diseases

József Gábor Joó, Éva Csatlós, Réka Brubel, Attila Bokor, Csaba Karabélyos, János Rigó

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Epigenetic effects influence the function of genes regulating the main physiological mechanisms. Some of these environmental factors may reduce or inhibit the function of these genes. The environmental effects on gene function may result in a change of the DNA structure leading to non-heritable phenotype changes. Epigenetic factors play an important etiological role in the development of numerous diseases in obstetrics and gynecology. Uterine fibroids probably have a complex etiological background including epigenetic mechanisms. The multifactorial aetiology of endometriosis suggests key roles for immunological and hormonal factors in the development of the diseases. These mechanisms are influenced by epigenetic factors, which may serve as therapeutic targets in the future. The possible in utero origin of polycystic ovary syndrome determines the main directions of research concerning epigenetic factors in the etiological background, with the hope of eventual prevention and/or treatment in the preconceptional period as well as during pregnancy care.

Translated title of the contributionEpigenetic background of the most common non-oncologic gynecological diseases
Original languageHungarian
Pages (from-to)492-499
Number of pages8
JournalOrvosi hetilap
Volume155
Issue number13
DOIs
Publication statusPublished - Mar 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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