Epidemiology and diagnosis of hypoparathyroidism

Bart L. Clarke, Edward M. Brown, Michael T. Collins, Harald Jüppner, P. Lakatos, Michael A. Levine, Michael M. Mannstadt, John P. Bilezikian, Anatoly F. Romanischen, Rajesh V. Thakker

Research output: Contribution to journalArticle

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Abstract

Context: Hypoparathyroidism is a disorder characterized by hypocalcemia due to insufficient secretion of PTH. Pseudohypoparathyroidism is a less common disorder due to target organ resistance to PTH. This report summarizes the results of the findings and recommendations of the Working Group on Epidemiology and Diagnosis of Hypoparathyroidism. Evidence Acquisition: Each contributing author reviewed the recent published literature regarding epidemiology and diagnosis of hypoparathyroidism using PubMed and other medical literature search engines. Evidence Synthesis: The prevalence of hypoparathyroidism is an estimated 37 per 100 000 person-years in the United States and 22 per 100 000 person-years in Denmark. The incidence inDenmarkis approximately 0.8 per 100 000 person-years. Estimates of prevalence and incidence of hypoparathyroidism are currently lacking inmostother countries. Hypoparathyroidism increases the risk of renal insufficiency, kidney stones, posterior subcapsular cataracts, and intracerebral calcifications, but it does not appear to increase overall mortality, cardiovascular disease, fractures, or malignancy. The diagnosis depends upon accurate measurement of PTH by second- And third-generation assays. The most common etiology is postsurgical hypoparathyroidism, followed by autoimmune disorders and rarely genetic disorders. Even more rare are etiologies including parathyroid gland infiltration, external radiation treatment, and radioactive iodine therapy for thyroid disease. Differentiation between these different etiologies is aided by the clinical presentation, serum biochemistries, and in some cases, genetic testing. Conclusions: Hypoparathyroidism is often associated with complications and comorbidities. It is important for endocrinologists and other physicians who care for these patients to be aware of recent advances in the epidemiology, diagnosis, and genetics of this disorder.

Original languageEnglish
Pages (from-to)2284-2299
Number of pages16
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

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Hypoparathyroidism
Epidemiology
Inborn Genetic Diseases
Biochemistry
Search engines
Infiltration
Iodine
Assays
Pseudohypoparathyroidism
Radiation
Search Engine
Parathyroid Glands
Kidney Calculi
Hypocalcemia
Thyroid Diseases
Incidence
Genetic Testing
Testing
Denmark
PubMed

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Clarke, B. L., Brown, E. M., Collins, M. T., Jüppner, H., Lakatos, P., Levine, M. A., ... Thakker, R. V. (2016). Epidemiology and diagnosis of hypoparathyroidism. Journal of Clinical Endocrinology and Metabolism, 101(6), 2284-2299. https://doi.org/10.1210/jc.2015-3908

Epidemiology and diagnosis of hypoparathyroidism. / Clarke, Bart L.; Brown, Edward M.; Collins, Michael T.; Jüppner, Harald; Lakatos, P.; Levine, Michael A.; Mannstadt, Michael M.; Bilezikian, John P.; Romanischen, Anatoly F.; Thakker, Rajesh V.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 101, No. 6, 01.06.2016, p. 2284-2299.

Research output: Contribution to journalArticle

Clarke, BL, Brown, EM, Collins, MT, Jüppner, H, Lakatos, P, Levine, MA, Mannstadt, MM, Bilezikian, JP, Romanischen, AF & Thakker, RV 2016, 'Epidemiology and diagnosis of hypoparathyroidism', Journal of Clinical Endocrinology and Metabolism, vol. 101, no. 6, pp. 2284-2299. https://doi.org/10.1210/jc.2015-3908
Clarke, Bart L. ; Brown, Edward M. ; Collins, Michael T. ; Jüppner, Harald ; Lakatos, P. ; Levine, Michael A. ; Mannstadt, Michael M. ; Bilezikian, John P. ; Romanischen, Anatoly F. ; Thakker, Rajesh V. / Epidemiology and diagnosis of hypoparathyroidism. In: Journal of Clinical Endocrinology and Metabolism. 2016 ; Vol. 101, No. 6. pp. 2284-2299.
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AU - Mannstadt, Michael M.

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