Epidemiological investigations and experimental model studies on exposure of pesticides

I. Dési, L. Nagymajtényi, H. Schulz, M. Nehéz

Research output: Contribution to journalArticle

Abstract

There is a world-wide tendency of decrease of the rural, agricultural population. This means that ever less people are forced to produce food for the whole community. This is possible only by an increasing use of modern means of production including chemization. As a consequence, both occupational exposure of the producers and foodborne exposure of the consumers is considerable. From the sixties till our days, there was a gradual but profound change in the amount and the chemical character of the used agrochemicals in the whole world and so it happened in Hungary, too. Chlorinated hydrocarbons notorious for their persistence, have been banned and replaced by environmentally safer organophosphates and carbamates. In spite of that, occupational and foodborne pesticide exposure remains a major problem. In both cases, spraymen and people with elevated susceptibility (pregnant and nursin gwomen, young children stc.) can be exposed with repeated low doses which may have unfavourable consequences for themselves and for the subsequent generations. Our department conducted epidemiological investigations concerning the genetic toxicity of pesticides, as well as experimental studies on animals in order to reveal the most susceptible target points of the toxic action within the organism, especially the influence on the functions of the nervous system and on the behaviour. We found early numerical aberrations in the chromosomes of plant protection workers immediatelly after spraying and even some time later too. The electrical activity of the brain of rats had been disturbed after pesticide administration both in regard of their spontaneous performance and answering on stimuli respectively. We found changes in their behaviour too. As indicated by the above, it is an important task of toxicology from the human health point of view to reduce the exposure of the sensitive groups and, by detection and follow-up of early alterations, to prevent the deterioration of the population's health state.

Original languageEnglish
Pages (from-to)370
Number of pages1
JournalZentralblatt fur Hygiene und Umweltmedizin
Volume200
Issue number4
Publication statusPublished - 1997

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Pesticides
Theoretical Models
Plant Chromosomes
Agrochemicals
Chlorinated Hydrocarbons
Toxic Actions
Carbamates
Organophosphates
Hungary
Health
Rural Population
Occupational Exposure
Chromosome Aberrations
Toxicology
Nervous System
Food
Brain
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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Epidemiological investigations and experimental model studies on exposure of pesticides. / Dési, I.; Nagymajtényi, L.; Schulz, H.; Nehéz, M.

In: Zentralblatt fur Hygiene und Umweltmedizin, Vol. 200, No. 4, 1997, p. 370.

Research output: Contribution to journalArticle

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