Epidemiological evidence against a role for C-reactive protein causing leptin resistance

M. K. Rutter, N. Sattar, A. Tajar, T. W. O'Neill, D. M. Lee, G. Bártfai, S. Boonen, F. F. Casanueva, J. D. Finn, G. Forti, A. Giwercman, T. S. Han, I. T. Huhtaniemi, K. Kula, M. E J Lean, N. Pendleton, M. Punab, A. J. Silman, D. Vanderschueren, G. LoweS. O'Rahilly, R. W. Morris, F. C. Wu, S. G. Wannamethee

Research output: Contribution to journalArticle

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Abstract

Objective: It has been suggested that elevated levels of C-reactive protein (CRP) might interfere with leptin signalling and contribute to leptin resistance. Our aim was to assess whether plasma levels of CRP influence leptin resistance in humans, and our hypothesis was that CRP levels would modify the cross-sectional relationships between leptin and measures of adiposity. Design and methods: We assessed four measures of adiposity: BMI, waist circumference, fat mass and body fat (%) in 2113 British Regional Heart Study (BRHS) men (mean (S.D.) age 69 (5) years), with replication in 760 (age 69 (6) years) European Male Ageing Study (EMAS) subjects. Results: In BRHS subjects, leptin correlated with CRP (Spearman's r=0.22, P

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalEuropean Journal of Endocrinology
Volume168
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Leptin
C-Reactive Protein
Adiposity
Waist Circumference
Adipose Tissue
Fats

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Rutter, M. K., Sattar, N., Tajar, A., O'Neill, T. W., Lee, D. M., Bártfai, G., ... Wannamethee, S. G. (2013). Epidemiological evidence against a role for C-reactive protein causing leptin resistance. European Journal of Endocrinology, 168(1), 101-106. https://doi.org/10.1530/EJE-12-0348

Epidemiological evidence against a role for C-reactive protein causing leptin resistance. / Rutter, M. K.; Sattar, N.; Tajar, A.; O'Neill, T. W.; Lee, D. M.; Bártfai, G.; Boonen, S.; Casanueva, F. F.; Finn, J. D.; Forti, G.; Giwercman, A.; Han, T. S.; Huhtaniemi, I. T.; Kula, K.; Lean, M. E J; Pendleton, N.; Punab, M.; Silman, A. J.; Vanderschueren, D.; Lowe, G.; O'Rahilly, S.; Morris, R. W.; Wu, F. C.; Wannamethee, S. G.

In: European Journal of Endocrinology, Vol. 168, No. 1, 01.2013, p. 101-106.

Research output: Contribution to journalArticle

Rutter, MK, Sattar, N, Tajar, A, O'Neill, TW, Lee, DM, Bártfai, G, Boonen, S, Casanueva, FF, Finn, JD, Forti, G, Giwercman, A, Han, TS, Huhtaniemi, IT, Kula, K, Lean, MEJ, Pendleton, N, Punab, M, Silman, AJ, Vanderschueren, D, Lowe, G, O'Rahilly, S, Morris, RW, Wu, FC & Wannamethee, SG 2013, 'Epidemiological evidence against a role for C-reactive protein causing leptin resistance', European Journal of Endocrinology, vol. 168, no. 1, pp. 101-106. https://doi.org/10.1530/EJE-12-0348
Rutter, M. K. ; Sattar, N. ; Tajar, A. ; O'Neill, T. W. ; Lee, D. M. ; Bártfai, G. ; Boonen, S. ; Casanueva, F. F. ; Finn, J. D. ; Forti, G. ; Giwercman, A. ; Han, T. S. ; Huhtaniemi, I. T. ; Kula, K. ; Lean, M. E J ; Pendleton, N. ; Punab, M. ; Silman, A. J. ; Vanderschueren, D. ; Lowe, G. ; O'Rahilly, S. ; Morris, R. W. ; Wu, F. C. ; Wannamethee, S. G. / Epidemiological evidence against a role for C-reactive protein causing leptin resistance. In: European Journal of Endocrinology. 2013 ; Vol. 168, No. 1. pp. 101-106.
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AU - Silman, A. J.

AU - Vanderschueren, D.

AU - Lowe, G.

AU - O'Rahilly, S.

AU - Morris, R. W.

AU - Wu, F. C.

AU - Wannamethee, S. G.

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