Epidemiological dynamics of norovirus GII. 4 variant new orleans 2009

Maria Cristina Medici, Fabio Tummolo, Simona De Grazia, Adriana Calderaro, Flora De Conto, Valentina Terio, Maria Chironna, Floriana Bonura, Marzia Pucci, K. Bányai, Vito Martella, Giovanni Maurizio Giammanco

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Norovirus (NoV) is one of the major causes of diarrhoeal disease with epidemic, outbreak and sporadic patterns in humans of all ages worldwide. NoVs of genotype GII.4 cause nearly 80–90% of all NoV infections in humans. Periodically, some GII.4 strains become predominant, generating major pandemic variants. Retrospective analysis of the GII.4 NoV strains detected in Italy between 2007 and 2013 indicated that the pandemic variant New Orleans 2009 emerged in Italy in the late 2009, became predominant in 2010–2011 and continued to circulate in a sporadic fashion until April 2013. Upon phylogenetic analysis based on the small diagnostic regions A and C, the late New Orleans 2009 NoVs circulating during 2011–2013 appeared to be genetically different from the early New Orleans 2009 strains that circulated in 2010. For a selection of strains, a 3.2 kb genome portion at the 3′ end was sequenced. In the partial ORF1 and in the full-length ORF2 and ORF3, the 2011–2013 New Orleans NoVs comprised at least three distinct genetic subclusters. By comparison with sequences retrieved from the databases, these subclusters were also found to circulate globally, suggesting that the local circulation reflected repeated introductions of different strains, rather than local selection of novel viruses. Phylogenetic subclustering did not correlate with changes in residues located in predicted putative capsid epitopes, although several changes affected the P2 domain in epitopes A, C, D and E.

Original languageEnglish
Pages (from-to)2919-2927
Number of pages9
JournalJournal of General Virology
Volume96
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

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Norovirus
Pandemics
Italy
Epitopes
Capsid
Disease Outbreaks
Genotype
Genome
Databases
Viruses
Infection

ASJC Scopus subject areas

  • Virology

Cite this

Medici, M. C., Tummolo, F., De Grazia, S., Calderaro, A., De Conto, F., Terio, V., ... Giammanco, G. M. (2015). Epidemiological dynamics of norovirus GII. 4 variant new orleans 2009. Journal of General Virology, 96(9), 2919-2927. https://doi.org/10.1099/vir.0.000204

Epidemiological dynamics of norovirus GII. 4 variant new orleans 2009. / Medici, Maria Cristina; Tummolo, Fabio; De Grazia, Simona; Calderaro, Adriana; De Conto, Flora; Terio, Valentina; Chironna, Maria; Bonura, Floriana; Pucci, Marzia; Bányai, K.; Martella, Vito; Giammanco, Giovanni Maurizio.

In: Journal of General Virology, Vol. 96, No. 9, 01.09.2015, p. 2919-2927.

Research output: Contribution to journalArticle

Medici, MC, Tummolo, F, De Grazia, S, Calderaro, A, De Conto, F, Terio, V, Chironna, M, Bonura, F, Pucci, M, Bányai, K, Martella, V & Giammanco, GM 2015, 'Epidemiological dynamics of norovirus GII. 4 variant new orleans 2009', Journal of General Virology, vol. 96, no. 9, pp. 2919-2927. https://doi.org/10.1099/vir.0.000204
Medici MC, Tummolo F, De Grazia S, Calderaro A, De Conto F, Terio V et al. Epidemiological dynamics of norovirus GII. 4 variant new orleans 2009. Journal of General Virology. 2015 Sep 1;96(9):2919-2927. https://doi.org/10.1099/vir.0.000204
Medici, Maria Cristina ; Tummolo, Fabio ; De Grazia, Simona ; Calderaro, Adriana ; De Conto, Flora ; Terio, Valentina ; Chironna, Maria ; Bonura, Floriana ; Pucci, Marzia ; Bányai, K. ; Martella, Vito ; Giammanco, Giovanni Maurizio. / Epidemiological dynamics of norovirus GII. 4 variant new orleans 2009. In: Journal of General Virology. 2015 ; Vol. 96, No. 9. pp. 2919-2927.
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