Egyes immunszuppresszív hatású vírusos betegségekkel kapcsolatos járványtani és klinikopatológiai megfigyelések

Translated title of the contribution: Epidemiological and clinicopathological observances relating to certain immunosuppressive viral diseases

Róbert Glávits, E. Ivánics

Research output: Contribution to journalArticle

Abstract

The authors review on the basis of their diagnostic data and observances the occurrence of immunosuppressive viral diseases in Hungary and their yearly prevalence. They support by their pathomorphological examinations that the cell lines (usually lymphoid cell lines) taking part in the functioning of the immune system are damaged during the pathogenesis of the mentioned diseases. Marek's disease virus, entering into the birds' body causes first the atrophy of lymphoid organs, damage of the lymphocytes. In 2-4 weeks old birds it causes the so-called transient paralysis with the paralysis of the neck and wings (lymphocytic encephalomyelitis in the central nervous system). In older, 1-6 months old birds neoplastic transformation of the (T-dependent) lymphocytes originating from the thymus ("neoplastic" form) can be seen, while in adult fowls inflammation of the peripheral nerves, classical fowl paralysis. Avian leucosis viruses and reticuloendotheliosis virus belonging to the group of retroviruses cause the neoplastic transformation of (B-dependent) lymphocytes originating from the bursa of Fabricius, while J-subtype avian leucosis virus that of myeloblasts and myelocytes of bone marrow origin. Lymphoid and myeloid leucosis were observed mainly in fowls, while reticuloendotheliosis in geese, turkeys and pheasants. Infectious bursitis occurred in Hungary in the seventies in the form of mild diarrhoea, atrophy of the bursa of Fabricius and 2-3 weeks later accumulation of diseases caused by different facultative pathogenic microorganisms. Highly pathogenic bursitis virus strains occurred from the second part of the eighties caused deaths already at the development of viraemia, severe acute haemorrhagic bursitis and haemorrhages in the body (mainly under the serous membranes and in the skeletal muscles, occasionally in the mucous membrane of the stomach) and hepatosis and nephrosis. Chicken anaemia was again detected in Hungary in 2004-2006 in more flocks, after a 15 year epidemic free period. The virus damage beside the erythroid and myeloid cell lines of the bone marrow, the lymphoid tissues. In turkey flocks got over adenovirus caused haemorrhagic enteritis because of the damage of spleen, and in goose and duck flock infected by circovirus because of the changes of bursa of Fabricius severe immunosupression (and consequent accumulation of diseases caused by facultative pathogenic microorganisms) can be observed. The authors attach great importance in the losses due to immunosuppressive viral diseases beside the damage of organs caused directly by viraemia and indirectly by neoplastic tissue proliferation to the losses due to secondary infections relating to the weakening of immune system and moreover to the risks of non-properly developed immunity, heterogenic at flock level following the vaccinations.

Original languageHungarian
Pages (from-to)328-335
Number of pages8
JournalMagyar Allatorvosok Lapja
Volume130
Issue number6
Publication statusPublished - 2008

Fingerprint

Bursa of Fabricius
Bursitis
immunosuppressive agents
Hungary
bursitis
Virus Diseases
Immunosuppressive Agents
Avian Leukosis Virus
Marek Disease
Birds
bursa of Fabricius
Geese
Granulocyte Precursor Cells
flocks
paralysis
Viremia
Lymphocytes
chickens
Avian leukosis virus
Viruses

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Egyes immunszuppresszív hatású vírusos betegségekkel kapcsolatos járványtani és klinikopatológiai megfigyelések. / Glávits, Róbert; Ivánics, E.

In: Magyar Allatorvosok Lapja, Vol. 130, No. 6, 2008, p. 328-335.

Research output: Contribution to journalArticle

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