Epidemic spread of recombinant noroviruses with four capsid types in Hungary

G. Reuter, Harry Vennema, Marion Koopmans, György Szücs

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe. Objectives: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary. Study design: From January 2001 to May 2004, samples containing "GGIIb/Hilversum polymerase" (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing. Results: Thirty-four (14.4%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n = 9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n = 6, 28%), Hu/NLV/GGII/Hawaii/1971 (n = 4, 19%) and Hu/NLV/GGII/Lordsdale/1993 (n = 1, 5%). Conclusions: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants - next to GGII-4/Lordsdale virus - causing epidemics of gastroenteritis in the last 4 years.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalJournal of Clinical Virology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2006

Fingerprint

Norovirus
Hungary
Capsid
Disease Outbreaks
Enteritis
Viruses
Genotype
Snow
Gastroenteritis
Mexico
Reverse Transcription
Food
Polymerase Chain Reaction

Keywords

  • Emerging
  • Norovirus
  • Outbreaks of gastroenteritis
  • Recombinant

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Epidemic spread of recombinant noroviruses with four capsid types in Hungary. / Reuter, G.; Vennema, Harry; Koopmans, Marion; Szücs, György.

In: Journal of Clinical Virology, Vol. 35, No. 1, 01.2006, p. 84-88.

Research output: Contribution to journalArticle

Reuter, G. ; Vennema, Harry ; Koopmans, Marion ; Szücs, György. / Epidemic spread of recombinant noroviruses with four capsid types in Hungary. In: Journal of Clinical Virology. 2006 ; Vol. 35, No. 1. pp. 84-88.
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