Eosinophil Counts in the Small Intestine and Colon of Children Without Apparent Gastrointestinal Disease

A Meta-analysis

Zoltán Kiss, Bálint Tél, Nelli Farkas, András Garami, A. Vincze, Judit Bajor, Patrícia Sarlós, Katalin Márta, Adrienn Eros, Alexandra Mikó, Zsolt Szakács, Dániel Pécsi, Péter Mátrai, Péter Hegyi, G. Verès

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The aim of the current study was to review the available data regarding eosinophil density in healthy tissue specimen originating from lower gastrointestinal segments to support suggested diagnostic cutoffs widely used in clinical practice. A systematic search was performed in 3 different databases. Calculations were made with Comprehensive MetaAnalysis software using random-effects model. Cell number measurements were pooled using the random-effects model and displayed on forest plots. Summary point estimations, 95% confidence intervals (CIs), and 95% prediction intervals (PIs) were calculated. The cumulative mean cell numbers were 8.26 (95% CI 4.71-11.80) with PI of 0-25.32 for the duodenum, 11.52 (95% CI 7.21-15.83) with PI 0-60.64 for the terminal ileum, and 11.10/high-power field (HPF) (95% CI 9.11-13.09) with PI of 0.96 to 21.23 in the large intestine and the rectum (HPF area = 0.2 mm 2). Previous studies included control patients with irritable bowel syndrome and functional gastrointestinal disorders. As mucosal eosinophils have a role in their pathomechanism, those patients should have been excluded. A critical point of interpreting reported data is that HPF is relative to the technical parameters of the microscopes; therefore, it is important to report findings in cell/mm 2. The present meta-analysis does not support the higher (>20) or lower (<10) cutoff values for healthy tissue eosinophil number. In contrast to the esophagus, there is no normal cutoff eosinophil density in the small intestine and the colon. A prospective, multicenter study to establish normal mucosal eosinophil density is clearly needed.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume67
Issue number1
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Gastrointestinal Diseases
Eosinophils
Small Intestine
Meta-Analysis
Colon
Confidence Intervals
Cell Count
Irritable Bowel Syndrome
Large Intestine
Ileum
Duodenum
Rectum
Esophagus
Multicenter Studies
Software
Databases
Prospective Studies

Keywords

  • cutoff criteria
  • eosinophilic colitis
  • eosinophilic gastroenteritis
  • gastrointestinal
  • physiological eosinophil density
  • primary eosinophil cell associated diseases

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Eosinophil Counts in the Small Intestine and Colon of Children Without Apparent Gastrointestinal Disease : A Meta-analysis. / Kiss, Zoltán; Tél, Bálint; Farkas, Nelli; Garami, András; Vincze, A.; Bajor, Judit; Sarlós, Patrícia; Márta, Katalin; Eros, Adrienn; Mikó, Alexandra; Szakács, Zsolt; Pécsi, Dániel; Mátrai, Péter; Hegyi, Péter; Verès, G.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 67, No. 1, 01.07.2018, p. 6-12.

Research output: Contribution to journalReview article

Kiss, Z, Tél, B, Farkas, N, Garami, A, Vincze, A, Bajor, J, Sarlós, P, Márta, K, Eros, A, Mikó, A, Szakács, Z, Pécsi, D, Mátrai, P, Hegyi, P & Verès, G 2018, 'Eosinophil Counts in the Small Intestine and Colon of Children Without Apparent Gastrointestinal Disease: A Meta-analysis', Journal of Pediatric Gastroenterology and Nutrition, vol. 67, no. 1, pp. 6-12. https://doi.org/10.1097/MPG.0000000000001904
Kiss, Zoltán ; Tél, Bálint ; Farkas, Nelli ; Garami, András ; Vincze, A. ; Bajor, Judit ; Sarlós, Patrícia ; Márta, Katalin ; Eros, Adrienn ; Mikó, Alexandra ; Szakács, Zsolt ; Pécsi, Dániel ; Mátrai, Péter ; Hegyi, Péter ; Verès, G. / Eosinophil Counts in the Small Intestine and Colon of Children Without Apparent Gastrointestinal Disease : A Meta-analysis. In: Journal of Pediatric Gastroenterology and Nutrition. 2018 ; Vol. 67, No. 1. pp. 6-12.
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