Enzyme-catalyzed synthesis of (R)- and (S)-3-heteroaryl-3-hydroxy-propanoic acids and their derivatives

Jürgen Brem, Csaba Paizs, Monica Ioana Toşa, E. Vass, Florin Dan Irimie

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Starting from the racemic 3-benzofuranyl- and 3-benzo[b]thiophenyl-3-hydroxypropanoic acid ethyl esters as substrates, various multistep enzymatic procedures were developed for the efficient synthesis of the corresponding highly enantiomerically enriched (R)- and (S)-3-heteroaryl-3-hydroxypropanoic acids.

Original languageEnglish
Pages (from-to)489-496
Number of pages8
JournalTetrahedron Asymmetry
Volume20
Issue number4
DOIs
Publication statusPublished - Mar 11 2009

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Propionates
enzymes
Enzymes
Derivatives
acids
Acids
synthesis
esters
Esters
Substrates
hydracrylic acid

ASJC Scopus subject areas

  • Organic Chemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Catalysis

Cite this

Enzyme-catalyzed synthesis of (R)- and (S)-3-heteroaryl-3-hydroxy-propanoic acids and their derivatives. / Brem, Jürgen; Paizs, Csaba; Toşa, Monica Ioana; Vass, E.; Irimie, Florin Dan.

In: Tetrahedron Asymmetry, Vol. 20, No. 4, 11.03.2009, p. 489-496.

Research output: Contribution to journalArticle

Brem, Jürgen ; Paizs, Csaba ; Toşa, Monica Ioana ; Vass, E. ; Irimie, Florin Dan. / Enzyme-catalyzed synthesis of (R)- and (S)-3-heteroaryl-3-hydroxy-propanoic acids and their derivatives. In: Tetrahedron Asymmetry. 2009 ; Vol. 20, No. 4. pp. 489-496.
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