Enzyme- and immunohistochemical localization of nitric oxide synthase in nerves of the porcine pancreas

Zsolt Ember, András Réti, Erzsébet Fehér

Research output: Contribution to journalArticle

7 Citations (Scopus)


The distribution of nitric oxide synthase (NOS) in neuronal and non- neuronal porcine pancreatic tissues was examined using nicotinamide adenine dinucleotide hydrogen phosphate diaphorase (NADPHd) enzymehistochemistry and neuronal type NOS immunohistochemistry. NOS-containing perikarya were regularly discernible in the pancreatic ganglia, whereas positive thin nerve fibers appeared within nerve bundles of the interlobular spaces and as thin varicose fibers in the vicinity of pancreatic blood vessels. Vascular endothelium showed intense staining for NADPHd and most of the islet cells were NOS immunoreactive. The above morphological findings indicate that nitrergic innervation of the porcine pancreas is very similar to that of the pancreata of other mammalian species and suggest that nitric oxide of both neuronal and extraneuronal origin may regulate blood flow and secretion of the porcine pancreas. (C) 2000 Published by Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalNeuroscience Letters
Issue number3
Publication statusPublished - Oct 13 2000



  • Enzymehistochemistry
  • Immunohistochemistry
  • Nicotinamide adenine dinucleotide hydrogen phosphate diaphorase
  • Nitric oxide
  • Nitric oxide synthase
  • Porcine pancreas

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this