Enzymatic resolutions of cyclic amino alcohol precursors

Helmut Hönig, Peter Seufer-Wasserthal, F. Fülöp

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Racemic butyrates of trans-2-azido as well as trans-2-nitro and trans-2-cyano cycloalkanols were hydrolysed to the corresponding optically active alcohols with the aid of lipases from Candida cylindracea and Pseudomonas sp. respectively. These precursors of amino alcohols could be produced in optical yields ranging from 85 to >98% e.e. Differences in the catalytic behaviour of the two enzymes depending on ring sizes were observed.

Original languageEnglish
Pages (from-to)2341-2345
Number of pages5
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number12
Publication statusPublished - 1989

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Amino Alcohols
Butyrates
Candida
Lipase
Alcohols
Enzymes

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Enzymatic resolutions of cyclic amino alcohol precursors. / Hönig, Helmut; Seufer-Wasserthal, Peter; Fülöp, F.

In: Journal of the Chemical Society, Perkin Transactions 1, No. 12, 1989, p. 2341-2345.

Research output: Contribution to journalArticle

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