Environmental trichlorfon and cluster of congenital abnormalities

A. E. Czeizel, Cs Elek, S. Gundy, J. Métneki, L. Tímár, E. Nemes, Z. Virágh, G. Tusnády, A. Reis, K. Sperling

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Of 15 live birth in one Hungarian village in 1989-90, 11 (73%) were affected by congenital abnormalities and 6 were twins. Of the 11, 4 had Down syndrome. Likely causes of such clusters (known teratogenic factors, familial inheritance, consanguinity) were excluded. A case-control study and environmental investigations pointed the finger of suspicion at the excessive use of trichlorfon at local fish farms. The content of this chemical was very high in fish (100 mg/kg) and several pregnant women, including all mothers of babies with Down syndrome, had consumed contamined fish in the critical period for the congenital abnormalities observed.

Original languageEnglish
Pages (from-to)539-542
Number of pages4
JournalThe Lancet
Issue number8844
Publication statusPublished - Feb 27 1993

ASJC Scopus subject areas

  • Medicine(all)

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    Czeizel, A. E., Elek, C., Gundy, S., Métneki, J., Tímár, L., Nemes, E., Virágh, Z., Tusnády, G., Reis, A., & Sperling, K. (1993). Environmental trichlorfon and cluster of congenital abnormalities. The Lancet, 341(8844), 539-542. https://doi.org/10.1016/0140-6736(93)90293-P