Environmental enrichment increases PACAP Levels in the CNS of adult rats

Gabor Horvath, P. Kiss, J. Németh, Beata Lelesz, A. Tamás, D. Reglodi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide, widely distributed throughout the body. It is involved in the regulation of various physiological and pathophysiological processes. Numerous studies have shown that PACAP is involved in the development of the central nervous system and has neuroprotective effects. Environmental enrichment is also protective in various injuries, partially through involvement of trophic factors. The interaction between PACAP levels in the brain and environmental effects has not been studied yet. The aim of the present study was to investigate whether environmental enrichment influences PACAP levels of different brain areas in rats. METHODS: Wistar rats were exposed to enriched environment in adulthood for 3 weeks. PACAP27- and PACAP38-like immunoreactivities were measured with a specific and sensitive radioimmunoassay in homogenates of different brain areas: brainstem, cerebellum, diencephalon and telencephalon. RESULTS: We found that levels of both PACAP27- and PACAP38-like immunoreactivities showed significant increases in most brain areas after a 3-week-long exposure to enriched conditions. Thus, similarly to several other CNS injuries, enriched environment induced elevation in PACAP levels. CONCLUSION: As PACAP has strong neuroprotective effects, the elevation observed after exposure to enriched environment is suggested to play a role in the protective effects of such an environment as part of the endogenous neuroprotective machinery in adult rats.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalNeuroendocrinology Letters
Volume36
Issue number2
Publication statusPublished - 2015

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Pituitary Adenylate Cyclase-Activating Polypeptide
Brain
Neuroprotective Agents
Physiological Phenomena
Diencephalon
Telencephalon
Wounds and Injuries
Neuropeptides
Cerebellum
Brain Stem
Radioimmunoassay
Wistar Rats
Central Nervous System

Keywords

  • Adult
  • CNS
  • Early postnatal
  • Environmental enrichment
  • PACAP
  • RIA

ASJC Scopus subject areas

  • Endocrinology
  • Endocrine and Autonomic Systems
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Medicine(all)

Cite this

Environmental enrichment increases PACAP Levels in the CNS of adult rats. / Horvath, Gabor; Kiss, P.; Németh, J.; Lelesz, Beata; Tamás, A.; Reglodi, D.

In: Neuroendocrinology Letters, Vol. 36, No. 2, 2015, p. 143-147.

Research output: Contribution to journalArticle

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AU - Kiss, P.

AU - Németh, J.

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AU - Reglodi, D.

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