Entropy and charge in molecular evolution - The case of phosphate

G. Arrhenius, B. Sales, S. Mojzsis, T. Lee

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Biopoesis, the creation of life, implies molecular evolution from simple components, randomly distributed and in a dilute state, to form highly organized, concentrated systems capable of metabolism, replication and mutation. This chain of events must involve environmental processes that can locally lower entropy in several steps; by specific selection from an indiscriminate mixture, by concentration from dilute solution, and in the case of the mineral-induced processes, by particular effectiveness in ordering and selective reaction, directed toward formation of functional biomolecules. Numerous circumstances provide support for the notion that negatively charged molecules were functionally required and geochemically available for biopoesis. Sulfite ion may have been important in bisulfite complex formation with simple aldehydes, facilitating the initial concentration by sorption of aldehydes in positively charged surface active minerals. Borate ion may have played a similar, albeit less investigated role in forming charged sugar complexes. Among anionic species, oligophosphate ions and charged phosphate esters are likely to have been of even more wide ranging importance, reflected in the continued need for phosphate in a proposed RNA world, and extending its central role to evolved biochemistry. Phosphorylation is shown to result in selective concentration by surface sorption of compounds, otherwise too dilute to support condensation reactions. It provides protection against rapid hydrolysis of sugars and, by selective concentration, induces the oligomerization of aldehydes. As a manifestation of life arisen, phosphate already appears in an organic context in the oldest preserved sedimentary record.

Original languageEnglish
Pages (from-to)503-522
Number of pages20
JournalJournal of Theoretical Biology
Volume187
Issue number4
DOIs
Publication statusPublished - Aug 21 1997

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Molecular Evolution
Entropy
entropy
Aldehydes
Phosphate
aldehydes
Phosphates
Charge
phosphates
Ions
ions
Sugars
Sorption
sorption
Minerals
minerals
sugars
bisulfites
borates
Sulfites

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Entropy and charge in molecular evolution - The case of phosphate. / Arrhenius, G.; Sales, B.; Mojzsis, S.; Lee, T.

In: Journal of Theoretical Biology, Vol. 187, No. 4, 21.08.1997, p. 503-522.

Research output: Contribution to journalArticle

Arrhenius, G. ; Sales, B. ; Mojzsis, S. ; Lee, T. / Entropy and charge in molecular evolution - The case of phosphate. In: Journal of Theoretical Biology. 1997 ; Vol. 187, No. 4. pp. 503-522.
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