Entrapment of microparticles in a microfluidic device: A model for isolation of circulating tumor cells

Adam Gyorgy Szelig, Csilla Kurdi, Marton Hartdegen, Kristof Ivan, Tamas Koszegi, Andras Jozsef Laki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Circulating tumor cells (CTCs) are shed from cancerous tumors even in the initial phase of malignant progression, enter the circulatory system, and migrate to distant organs to form metastases which lead to the death of most patients with cancer. Identification and characterization of CTCs provides a great opportunity to study, monitor, and potentially interfere with the metastatic process. The efficient entrapment of CTCs from whole blood means dealing with rare events and is still a challenging research field even nowadays. Using microfluidic devices, the efficiency of cell entrapment can be increased significantly. For this purpose we have developed a microfluidic device capable of isolation of microparticles and/or cells based on size exclusion technique. In the present work, we show our results on filtration of fluorescent microbeads as model particles in PBS and in human EDTA-blood as well, to determine the capturing efficiency of our microfluidic device with a novel geometric structure.

Original languageEnglish
Title of host publication2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1-4
Number of pages4
ISBN (Electronic)9781509058037
DOIs
Publication statusPublished - Mar 23 2018
Event2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Torino, Italy
Duration: Oct 19 2017Oct 21 2017

Publication series

Name2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
Volume2018-January

Other

Other2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017
CountryItaly
CityTorino
Period10/19/1710/21/17

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Instrumentation

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    Szelig, A. G., Kurdi, C., Hartdegen, M., Ivan, K., Koszegi, T., & Laki, A. J. (2018). Entrapment of microparticles in a microfluidic device: A model for isolation of circulating tumor cells. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings (pp. 1-4). (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings; Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIOCAS.2017.8325228