Entorhinal cortical innervation of parvalbumin-containing neurons (basket and chandelier cells) in the rat ammon's horn

Jozsef Kiss, Gyorgy Buzsaki, Jon S. Morrow, Susan B. Glantz, Csaba Leranth

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Physiological data suggest that in the CA1-CA3 hippocampal areas of rats, entorhinal cortical efferents directly influence the activity of interneurons, in addition to pyramidal cells. To verify this hypothesis, the following experiments were performed: 1) light microscopic double-immunostaining for parvalbumin and the anterograde tracer Phaseolus vulgaris-leucoagglutinin injected into the entorhinal cortex; 2) light and electron microscopic analysis of cleaved spectrin-immunostained (i.e., degenerating axons and boutons) hippocampal sections following entorhinal cortex lesion; and 3) an electron microscopic study of parvalbumin-immunostained hippocampal sections after entorhinal cortex lesion. The results demonstrate that in the stratum lacunosum-moleculare of the CA1 and CA3 regions, entorhinal cortical axons form asymmetric synaptic contacts on parvalbumin-containing dendritic shafts. In the stratum lacunosum-moleculare, parvalbumin-immunoreactive dendrites represent processes of GABAergic, inhibitory basket and chandelier cells; these interneurons innervate the perisomatic area and axon initial segments of pyramidal cells, respectively. A feed-forward activation of these neurons by the entorhinal input may explain the strong, short-latency inhibition of pyramidal cells.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalHippocampus
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 1 1996

Keywords

  • Anterograde tracing
  • Cleaved spectrin
  • Degeneration
  • Feed-forward inhibition
  • PHA-L
  • Theta activity

ASJC Scopus subject areas

  • Cognitive Neuroscience

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